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Protein

Ribonuclease HII

Gene

rnhB

Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36Divalent metal cationUniRule annotation1
Metal bindingi37Divalent metal cationUniRule annotation1
Metal bindingi130Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:MAB_3222c
OrganismiMycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
Taxonomic identifieri561007 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium abscessus
Proteomesi
  • UP000007137 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000916351 – 234Ribonuclease HIIAdd BLAST234

Interactioni

Protein-protein interaction databases

STRINGi561007.MAB_3222c.

Structurei

3D structure databases

ProteinModelPortaliB1MDH9.
SMRiB1MDH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UH2. Bacteria.
COG0164. LUCA.
HOGENOMiHOG000100288.
OMAiNILHASM.

Family and domain databases

CDDicd07182. RNase_HII_bacteria_HII_like. 1 hit.
Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B. 1 hit.
InterProiView protein in InterPro
IPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
PANTHERiPTHR10954. PTHR10954. 1 hit.
PTHR10954:SF15. PTHR10954:SF15. 1 hit.
PfamiView protein in Pfam
PF01351. RNase_HII. 1 hit.
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

B1MDH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSWPPRTV IRKASGLRTL ELTLDRVGLG PVAGVDEAGR GACAGPLVIA
60 70 80 90 100
ACVLGSNQRK SLAALNDSKK LTEKMRETLF PLICRYAEAY HVVSVPADEV
110 120 130 140 150
DRIGVHVANI EGMRRAVAGL GVKPGYVLTD GFRVPGLPVP SLPVIGGDAS
160 170 180 190 200
AACIAAASVL AKVSRDRVMV NMDSDHPGYG FAVHKGYSTA VHTEALRRLG
210 220 230
PSAQHRQSFV NVRNAAMGSS LMRPLAPRES DTGG
Length:234
Mass (Da):24,620
Last modified:April 29, 2008 - v1
Checksum:iF4A86FCCD225D041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU458896 Genomic DNA. Translation: CAM63298.1.

Genome annotation databases

EnsemblBacteriaiCAM63298; CAM63298; MAB_3222c.

Similar proteinsi

Entry informationi

Entry nameiRNH2_MYCA9
AccessioniPrimary (citable) accession number: B1MDH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: September 27, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families