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Protein

Ribonuclease HII

Gene

rnhB

Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Divalent metal cationUniRule annotation
Metal bindingi37 – 371Divalent metal cationUniRule annotation
Metal bindingi130 – 1301Divalent metal cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciMABS36809-WGS:GSQO-3236-MONOMER.
MABS561007:GJTG-3236-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:MAB_3222c
OrganismiMycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
Taxonomic identifieri561007 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium abscessus
Proteomesi
  • UP000007137 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Ribonuclease HIIPRO_1000091635Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561007.MAB_3222c.

Structurei

3D structure databases

ProteinModelPortaliB1MDH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UH2. Bacteria.
COG0164. LUCA.
HOGENOMiHOG000100288.
OMAiGFASHKG.
OrthoDBiEOG6BKJC8.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

B1MDH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSWPPRTV IRKASGLRTL ELTLDRVGLG PVAGVDEAGR GACAGPLVIA
60 70 80 90 100
ACVLGSNQRK SLAALNDSKK LTEKMRETLF PLICRYAEAY HVVSVPADEV
110 120 130 140 150
DRIGVHVANI EGMRRAVAGL GVKPGYVLTD GFRVPGLPVP SLPVIGGDAS
160 170 180 190 200
AACIAAASVL AKVSRDRVMV NMDSDHPGYG FAVHKGYSTA VHTEALRRLG
210 220 230
PSAQHRQSFV NVRNAAMGSS LMRPLAPRES DTGG
Length:234
Mass (Da):24,620
Last modified:April 29, 2008 - v1
Checksum:iF4A86FCCD225D041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU458896 Genomic DNA. Translation: CAM63298.1.

Genome annotation databases

EnsemblBacteriaiCAM63298; CAM63298; MAB_3222c.
PATRICi17978214. VBIMycAbs55940_3280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU458896 Genomic DNA. Translation: CAM63298.1.

3D structure databases

ProteinModelPortaliB1MDH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi561007.MAB_3222c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM63298; CAM63298; MAB_3222c.
PATRICi17978214. VBIMycAbs55940_3280.

Phylogenomic databases

eggNOGiENOG4108UH2. Bacteria.
COG0164. LUCA.
HOGENOMiHOG000100288.
OMAiGFASHKG.
OrthoDBiEOG6BKJC8.

Enzyme and pathway databases

BioCyciMABS36809-WGS:GSQO-3236-MONOMER.
MABS561007:GJTG-3236-MONOMER.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus."
    Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Macheras E., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
    PLoS ONE 4:E5660-E5660(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543.

Entry informationi

Entry nameiRNH2_MYCA9
AccessioniPrimary (citable) accession number: B1MDH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: December 9, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.