Skip Header

Contribute Send feedback
Read comments (?) or add your own

B1MDC7 (B1MDC7_MYCA9) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183
Ordered Locus Names:MAB_3171c
OrganismMycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]
Taxonomic identifier561007 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding11 – 4030NADP By similarity HAMAP MF_00183

Sites

Metal binding1441Divalent metal cation By similarity HAMAP MF_00183
Metal binding1461Divalent metal cation By similarity HAMAP MF_00183
Metal binding2151Divalent metal cation By similarity HAMAP MF_00183
Binding site1211Substrate By similarity HAMAP MF_00183
Binding site1461Substrate By similarity HAMAP MF_00183
Binding site1701Substrate By similarity HAMAP MF_00183
Binding site1931Substrate By similarity HAMAP MF_00183
Binding site2151Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
B1MDC7 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: ED176DDC6CFE8394

FASTA38940,306
        10         20         30         40         50         60 
MSSEVCRVLL LGSTGSIGTQ ALEVIAANPE RFEVVGLAAG GGNVELLRQQ ISETGVTNVA 

        70         80         90        100        110        120 
VADERAAVRL DIPVLSGPDA VTELVENTEA DVVLNALVGA LGLRPTLAAL KSGARLALAN 

       130        140        150        160        170        180 
KESLVAGGPL VTKAAAPGQI VPVDSEHSAL AQCLRGGTRG EVAQLILTAS GGPFRGWTAQ 

       190        200        210        220        230        240 
QLTAVTPEQA GAHPTWSMGP MNTLNSASLV NKGLELIETH LLFGVPYRQI GVVVHPQSIV 

       250        260        270        280        290        300 
HSMVTFTDGS TLAQASPPDM KLPIALALGW PDRVPAAASA CDFSTASTWE FEPLDAQVFP 

       310        320        330        340        350        360 
AVDLARSAGE AGGCMTAVYN AANETAAAAF LDGRIGFRSI VRTIADVLDV ASQWEGTSAE 

       370        380 
PATVDDVLDA QRWAGQQAAQ FIFAEENRT

« Hide

References

[1]"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
Genoscope
Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU458896 Genomic DNA. Translation: CAM63248.1.
RefSeqYP_001703902.1. NC_010397.1.

3D structure databases

ProteinModelPortalB1MDC7.
SMRB1MDC7. Positions 7-382.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1MDC7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000006665; EBMYCP00000006604; EBMYCG00000006663.
GeneID5965676.
GenomeReviewsGene locus MAB_3171c in contig CU458896_GR.
KEGGmab:MAB_3171c.
PATRIC17978106. VBIMycAbs55940_3226.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016490.
HOGENOMHBG430762.
OMAIHSMVEY.
ProtClustDBPRK05447.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1MDC7_MYCA9
AccessionPrimary (citable) accession number: B1MDC7
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info