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B1MD62

- PNP_MYCA9

UniProt

B1MD62 - PNP_MYCA9

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi527 – 5271MagnesiumUniRule annotation
Metal bindingi533 – 5331MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMABS36809-WGS:GSQO-3121-MONOMER.
MABS561007:GJTG-3121-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:MAB_3106c
OrganismiMycobacterium abscessus (strain ATCC 19977 / DSM 44196)
Taxonomic identifieri561007 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium abscessus
ProteomesiUP000007137: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Polyribonucleotide nucleotidyltransferasePRO_1000147933Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561007.MAB_3106c.

Structurei

3D structure databases

ProteinModelPortaliB1MD62.
SMRiB1MD62. Positions 13-727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini593 – 65260KHUniRule annotationAdd
BLAST
Domaini664 – 73370S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1MD62-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVTEIEEGI FESTATIDNG SFGTRTIRFE TGRLALQAAG SVVAYLDDET
60 70 80 90 100
MLLSTTAASK TPKDHFDFFP LTVDVEERMY AAGRIPGSFF RREGRPSTDA
110 120 130 140 150
ILTCRLIDRP LRPSFVSGLR NEIQVVVTVL SLNPADLYDV LAINAASAST
160 170 180 190 200
QLAGLPFSGP VGGVRVALIE GQWVAFPTVE QLEKAVFDMV VAGRKVGTAG
210 220 230 240 250
DSDVAIMMVE AEATDNVIAL IDGGAGAPTE TVVAEGLEAA KPFIAALCTA
260 270 280 290 300
QEELAGSAAK PTGEFPLFPD YQDDVYAAVA AVATEPLSQA LSIAGKAERD
310 320 330 340 350
EKTDEIKVDV LGRLQEGFDG REKEIGAAFR SLTKKLVRQR ILKDQFRIDG
360 370 380 390 400
RGVTDIRALS AEVAVIPRAH GSALFERGET QIMGVTTLDM IKMAQQVDSL
410 420 430 440 450
GPETTKRYMH HYNFPPFSTG ETGRVGSPKR REIGHGALAE RALIPVLPSI
460 470 480 490 500
EEFPYAIRQV SEALGSNGST SMGSVCASTL ALLNAGVPLK APVAGIAMGL
510 520 530 540 550
VSDDIELADG TAERRFVALT DILGAEDAFG DMDFKVAGTK DFVTALQLDT
560 570 580 590 600
KLDGIPSQVL AAALSQAKDA RTTILEVMAE AIDAPDEMSP YAPRITTIKV
610 620 630 640 650
PVDKIGEVIG PKGKMINSIT EETGANISIE DDGTVFVGAA DGASAQAAID
660 670 680 690 700
KINAIANPQL PKIGERFLGT VVKTTDFGAF VSLLPGRDGL VHISKLGKGK
710 720 730 740 750
RIAKVEDVVK VGDKIQVEIA DIDNRGKISL VPVGEEDAAE APAPAEAQPA

DAVTQ
Length:755
Mass (Da):79,793
Last modified:April 29, 2008 - v1
Checksum:i543EF42B42C972F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU458896 Genomic DNA. Translation: CAM63183.1.
RefSeqiYP_001703837.1. NC_010397.1.

Genome annotation databases

EnsemblBacteriaiCAM63183; CAM63183; MAB_3106c.
GeneIDi5965612.
KEGGimab:MAB_3106c.
PATRICi17977968. VBIMycAbs55940_3157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU458896 Genomic DNA. Translation: CAM63183.1 .
RefSeqi YP_001703837.1. NC_010397.1.

3D structure databases

ProteinModelPortali B1MD62.
SMRi B1MD62. Positions 13-727.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561007.MAB_3106c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM63183 ; CAM63183 ; MAB_3106c .
GeneIDi 5965612.
KEGGi mab:MAB_3106c.
PATRICi 17977968. VBIMycAbs55940_3157.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci MABS36809-WGS:GSQO-3121-MONOMER.
MABS561007:GJTG-3121-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
    Genoscope
    Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19977 / DSM 44196.

Entry informationi

Entry nameiPNP_MYCA9
AccessioniPrimary (citable) accession number: B1MD62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3