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B1MCW0 (B1MCW0_MYCA9) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116
Gene names
Name:dut HAMAP MF_00116
Ordered Locus Names:MAB_3003c
OrganismMycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]
Taxonomic identifier561007 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116 SAAS SAAS008181

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 SAAS SAAS008181

Cofactor

Magnesium By similarity. HAMAP MF_00116 SAAS SAAS008181

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116

Subunit structure

Homotrimer By similarity. HAMAP MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region60 – 623Substrate binding By similarity HAMAP MF_00116
Region77 – 793Substrate binding By similarity HAMAP MF_00116

Sites

Binding site731Substrate By similarity HAMAP MF_00116
Binding site871Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00116

Sequences

Sequence LengthMass (Da)Tools
B1MCW0 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 031202449C2A230B

FASTA15015,502
        10         20         30         40         50         60 
MAIVRLDREL PLPSRAHADD AGVDLYSAED VVIEPGRRTL VGTGIAVAIP SGMVGLVHPR 

        70         80         90        100        110        120 
SGLAARVGLS IVNSPGTIDA GYRGEVKVNL INLDSEVPIV IARGDRIAQL LVQQVELPEL 

       130        140        150 
VEVDSFDEAG LAVTTRGAGG YGSSGGHASL

« Hide

References

[1]"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
Genoscope
Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU458896 Genomic DNA. Translation: CAM63081.1.
RefSeqYP_001703735.1. NC_010397.1.

3D structure databases

ProteinModelPortalB1MCW0.
SMRB1MCW0. Positions 1-140.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1MCW0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000004842; EBMYCP00000004781; EBMYCG00000004840.
GeneID5965510.
GenomeReviewsGene locus MAB_3003c in contig CU458896_GR.
KEGGmab:MAB_3003c.
PATRIC17977760. VBIMycAbs55940_3053.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017683.
HOGENOMHBG436079.
OMAKIAQMVI.
ProtClustDBPRK00601.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
[Tree]
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
KOK01520.
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. Dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1MCW0_MYCA9
AccessionPrimary (citable) accession number: B1MCW0
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info