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B1MCU3 (B1MCU3_MYCA9) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase HAMAP MF_00218
Short name=UPD HAMAP MF_00218
Short name=URO-D HAMAP MF_00218
EC=4.1.1.37 HAMAP MF_00218
Gene names
Name:hemE HAMAP MF_00218
Ordered Locus Names:MAB_2986c
OrganismMycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]
Taxonomic identifier561007 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218 SAAS SAAS006361

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218 RuleBase RU000554 SAAS SAAS006361

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen III from 5-aminolevulinate: step 4/4. RuleBase RU000554

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218 SAAS SAAS006361

Subunit structure

Homodimer By similarity. HAMAP MF_00218 SAAS SAAS006361

Subcellular location

Cytoplasm By similarity HAMAP MF_00218 SAAS SAAS006361.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP MF_00218 RuleBase RU004169

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region70 – 745Substrate binding By similarity HAMAP MF_00218

Sites

Binding site1191Substrate By similarity HAMAP MF_00218
Binding site1941Substrate By similarity HAMAP MF_00218
Binding site2491Substrate By similarity HAMAP MF_00218
Binding site3681Substrate By similarity HAMAP MF_00218
Site1191Transition state stabilizer By similarity HAMAP MF_00218

Sequences

Sequence LengthMass (Da)Tools
B1MCU3 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 90BEEA57794DAF26

FASTA38940,495
        10         20         30         40         50         60 
MDGSAPGRHA PAGAPCEAVM AAWAVMTGLN EDSATAAQTT SKTRRDLPLS PYLVAAAGGV 

        70         80         90        100        110        120 
PSHPPVWFMR QAGRSLPEYR AVRADHAMLD ACFNPELVCE ITLQPIRRHR VDAAILFSDI 

       130        140        150        160        170        180 
VVPLKAAGID LDIVPDVGPV IANPVRTTAD VAALPRLEPG QVEAVSAAVR LLVGELGATP 

       190        200        210        220        230        240 
LIGFAGAPFT LASYLVEGGP SRHHQRTKAL LLGDPQTWHA LMTALTDITI AFLRAQLDAG 

       250        260        270        280        290        300 
VDALQLFDSW AGALSLADYR AAVLPHSTRI FQEFAGVGVP MTHFGVGTAE LLGAMGEAGA 

       310        320        330        340        350        360 
TVVGVDWRTP LNVAASRVGS GKALQGNLDP AVLLAGWPVV ESEVRRIVAE GRQAVADGAA 

       370        380 
GHIFNLGHGV LPDTDPAVLT DAAALVHSL

« Hide

References

[1]"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
Genoscope
Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU458896 Genomic DNA. Translation: CAM63064.1.
RefSeqYP_001703718.1. NC_010397.1.

3D structure databases

ProteinModelPortalB1MCU3.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1MCU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000008208; EBMYCP00000008147; EBMYCG00000008206.
GeneID5965493.
GenomeReviewsGene locus MAB_2986c in contig CU458896_GR.
KEGGmab:MAB_2986c.
PATRIC17977726. VBIMycAbs55940_3036.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016469.
HOGENOMHBG628392.
OMAPRIHFGV.

Family and domain databases

HAMAPMF_00218. URO_D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1MCU3_MYCA9
AccessionPrimary (citable) accession number: B1MCU3
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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