B1MCD9 (PYRB_MYCA9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	MAB_2831c

Organism

Mycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]

Taxonomic identifier

561007 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000088778

Sequences

	Sequence		Length	Mass (Da)
	B1MCD9 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 51EF6B6E936EB6A1	FASTA	317	33,651
	10 20 30 40 50 60 MRHLLSAADL TRDEATAILD DADRFLQALA GREVKKLPTL RGRTIITMFY ENSTRTRVSF 70 80 90 100 110 120 EVAGKWMSAD VINVSASGSS VAKGESLRDT ALTLRAIGAD ALIVRHPASG VAAQLAQWTA 130 140 150 160 170 180 EGEGGPAVVN AGDGTHEHPT QALLDALTIR QRLGSLEGRR VVIVGDILHS RVARSNALLL 190 200 210 220 230 240 NTFGAEVVLV APPTLLPVGV GTWPVTVTHD LDAELPGADA VLMLRVQAER MTGGFFPSAR 250 260 270 280 290 300 EYSVLYGMSE ARQRLLPEHA VVLHPGPMLR GMEIASAVAD SSQSGVLQQV SNGVHIRMAV 310 LFHLLVGSSD SPEAVPA

References

[1]

"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus." Genoscope Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19977 / DSM 44196.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU458896 Genomic DNA. Translation: CAM62910.1.
RefSeq	YP_001703564.1. NC_010397.1.
3D structure databases
ProteinModelPortal	B1MCD9.
ModBase	Search...
Protein-protein interaction databases
STRING	B1MCD9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000006803; EBMYCP00000006742; EBMYCG00000006801.
GeneID	5965339.
GenomeReviews	Gene locus MAB_2831c in contig CU458896_GR.
KEGG	mab:MAB_2831c.
PATRIC	17977402. VBIMycAbs55940_2878.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016463.
HOGENOM	HBG579429.
OMA	LQRERMS.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	MABS561007:MAB_2831C-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_MYCA9

Accession

Primary (citable) accession number: B1MCD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program