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B1MC86 (PGK_MYCA9) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:MAB_2778c
OrganismMycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]
Taxonomic identifier561007 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium abscessus

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 412412Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000096357

Regions

Nucleotide binding368 – 3714ATP By similarity
Region24 – 263Substrate binding By similarity
Region67 – 704Substrate binding By similarity

Sites

Binding site441Substrate By similarity
Binding site1261Substrate By similarity
Binding site1701Substrate By similarity
Binding site2201ATP By similarity
Binding site3081ATP; via carbonyl oxygen By similarity
Binding site3391ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B1MC86 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 61828C1555D57D69

FASTA41242,264
        10         20         30         40         50         60 
MAIKSLNDLL AEGVSGKGVL VRSDLNVPLE YLDGNIAHIS DPGRIVASVP TIRALAGAGA 

        70         80         90        100        110        120 
KVIVTAHLGR PDGKPDPKLS LAPVGAALGE LLGQHVQVAG DVVGTDALAR AEGLTDGDVL 

       130        140        150        160        170        180 
LLENIRFDPR ETSKDDAQRL ALARELAELV GGPTGTGGAF VSDGFGVVHR KQASVYDVAT 

       190        200        210        220        230        240 
LLPHYAGGLV AAEVEVLRVL TASTERPYAV VLGGSKVSDK LAVIESLATK ADSLVIGGGM 

       250        260        270        280        290        300 
CFTFLAAQGL PVGKSLVQLE MVDTCKRLLD TYADVIHLPM DIVAADEFAA DSPSEIVAAD 

       310        320        330        340        350        360 
AIPDSKMGLD IGPESVKRFA AVLSNAKTIF WNGPMGVFEF PAFAAGTRGV AEAIIAATEK 

       370        380        390        400        410 
GAFSVVGGGD SAAAVRALDL PDDGFSHIST GGGASLEYLE GKVLPGIDVL ED 

« Hide

References

[1]"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
Genoscope
Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19977 / DSM 44196.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU458896 Genomic DNA. Translation: CAM62857.1.
RefSeqYP_001703511.1. NC_010397.1.

3D structure databases

ProteinModelPortalB1MC86.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING561007.MAB_2778c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM62857; CAM62857; MAB_2778c.
GeneID5965286.
KEGGmab:MAB_2778c.
PATRIC17977294. VBIMycAbs55940_2824.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAAGHPVGK.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycMABS36809-WGS:GSQO-2791-MONOMER.
MABS561007:GJTG-2791-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_MYCA9
AccessionPrimary (citable) accession number: B1MC86
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways