B1MBV4 (TRPC_MYCA9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	MAB_2645c

Organism

Mycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]

Taxonomic identifier

561007 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000095871

Sequences

	Sequence		Length	Mass (Da)
	B1MBV4 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 5A6488A9D70E9B5A	FASTA	272	27,968
	10 20 30 40 50 60 MSSGTVLDSI LDGVRADVAA REAVVDLATV KAAAKAAPKP LDVMAALREP GIAVIAEVKR 70 80 90 100 110 120 ASPSRGALAE ISDPAELAKA YEDGGARIIS VLTEGRRFNG SLDDLDSVRA AVSVPVLRKD 130 140 150 160 170 180 FVISPYQIHE ARAHGADLIL LIVAALEQTA LVSLLDRTES LGMTALVEVH TEEEADRALS 190 200 210 220 230 240 AGASVIGVNA RDLKTLEIDR DCFSRIAPGL PSGVIRIAES GVRGTADLLA YAGAGADAVL 250 260 270 VGEGLVTSGD PRGAVADLVT AGTHPSCPKP AR

References

[1]

"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus." Genoscope Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19977 / DSM 44196.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU458896 Genomic DNA. Translation: CAM62725.1.
RefSeq	YP_001703379.1. NC_010397.1.
3D structure databases
ProteinModelPortal	B1MBV4.
ModBase	Search...
Protein-protein interaction databases
STRING	B1MBV4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000005333; EBMYCP00000005272; EBMYCG00000005331.
GeneID	5965154.
GenomeReviews	Gene locus MAB_2645c in contig CU458896_GR.
KEGG	mab:MAB_2645c.
PATRIC	17977020. VBIMycAbs55940_2687.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017090.
HOGENOM	HBG540956.
OMA	VESLGMT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	MABS561007:MAB_2645C-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_MYCA9

Accession

Primary (citable) accession number: B1MBV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program