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Protein

Catalase-peroxidase

Gene

katG

Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei105 – 1051Transition state stabilizerUniRule annotation
Active sitei109 – 1091Proton acceptorUniRule annotation
Metal bindingi272 – 2721Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMABS36809-WGS:GSQO-2484-MONOMER.
MABS561007:GJTG-2484-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:MAB_2470c
OrganismiMycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
Taxonomic identifieri561007 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium abscessus
Proteomesi
  • UP000007137 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Catalase-peroxidasePRO_0000354834Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki108 ↔ 231Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-257)UniRule annotation
Cross-linki231 ↔ 257Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-108)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi561007.MAB_2470c.

Structurei

3D structure databases

ProteinModelPortaliB1MBD0.
SMRiB1MBD0. Positions 26-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1MBD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEHPPIAE ANSQPSNGCP VAGGRLNYPV EGGNANREWW PTQLNLQILK
60 70 80 90 100
KNPPAANPLG EDFDYAKAVQ TIDVDQLKAD VAKVLTDSQD WWPADFGNYG
110 120 130 140 150
PMFIRMAWHA AGTYRVGDGR GGAGAGMQRF APLNSWPDNV LLDRARRLLW
160 170 180 190 200
PVKKKYGNKL SWADLIVFAG NHAMDTMGFK TFGFAFGRED RWEPEQDVYW
210 220 230 240 250
GPEHTWLGDE RYTGDRDLEN PLAAVQMGLI YVNPEGPNGN PDPLAAAIDI
260 270 280 290 300
RETFGRMAMN DEETAALIVG GHTFGKTHGA GDAGLVGPDP EAAPLEQMGI
310 320 330 340 350
GWKSAFGSGK GNDAIGSGLE VIWTHTPTKW DNSFLEILYG NEWELTKSPA
360 370 380 390 400
GAHQWKPKDG GWANSVPMAQ GTGKTHPSML TTDLSMRFDP IYGQITKRWL
410 420 430 440 450
DHPEELADAY AKAWYKLIHR DLGPLSRYLG PLVPKETLPW QDVIPVSETN
460 470 480 490 500
VGADDVAELK KQVLASGLTV PQLVSTAWKA AASYRNSDKR GGANGGRIRL
510 520 530 540 550
QPQAGWESNE PDELAQVIRI LEGVQESFNA GDKKISFADL VVLGGAAAVE
560 570 580 590 600
KAARDAGFDI TVPFTPGRGD ATQEQTDVES FSYLEPTADG FRNYLGKGAQ
610 620 630 640 650
IPAEYKLIDR ANLLALSPPE LAVLVGGLRV LGANYQGSEL GVLTDRPGTL
660 670 680 690 700
TNDFFVNLVD MGTEWTPSPA DDGTYVGTDR ATGASKWTAS RVDLVFGANS
710 720 730
ELRALAEVYA QDDAQEKFAK DFVAAWVKVS DADRFDVR
Length:738
Mass (Da):80,406
Last modified:April 29, 2008 - v1
Checksum:i64FD248A6E87F843
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti719 – 7191A → V in ABJ97682 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ872161 Genomic DNA. Translation: ABJ97682.1.
CU458896 Genomic DNA. Translation: CAM62551.1.

Genome annotation databases

EnsemblBacteriaiCAM62551; CAM62551; MAB_2470c.
PATRICi17976672. VBIMycAbs55940_2513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ872161 Genomic DNA. Translation: ABJ97682.1.
CU458896 Genomic DNA. Translation: CAM62551.1.

3D structure databases

ProteinModelPortaliB1MBD0.
SMRiB1MBD0. Positions 26-738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi561007.MAB_2470c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM62551; CAM62551; MAB_2470c.
PATRICi17976672. VBIMycAbs55940_2513.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
OMAiIAEVYAC.

Enzyme and pathway databases

BioCyciMABS36809-WGS:GSQO-2484-MONOMER.
MABS561007:GJTG-2484-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_MYCA9
AccessioniPrimary (citable) accession number: B1MBD0
Secondary accession number(s): A0F0B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 29, 2008
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.