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B1MB73 (B1MB73_MYCA9) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:MAB_2413c
OrganismMycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]
Taxonomic identifier561007 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding18 – 236NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding41 – 433NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding83 – 853NADP By similarity PIRSR PIRSR000109-3
Region137 – 1393Substrate binding By similarity PIRSR PIRSR000109-2
Region194 – 1952Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1911Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1981Proton donor By similarity PIRSR PIRSR000109-1
Binding site1111NADP By similarity PIRSR PIRSR000109-3
Binding site1111Substrate By similarity PIRSR PIRSR000109-2
Binding site1991Substrate By similarity PIRSR PIRSR000109-2
Binding site2691Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2961Substrate By similarity PIRSR PIRSR000109-2
Binding site4541Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4601Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
B1MB73 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: DFC9246B56D6C64E

FASTA48451,664
        10         20         30         40         50         60 
MTAADGSAQG KAQIGVTGLA VMGSNIARNF ARHGYTVALH NRSIAKTDAL LAEHGSEGNF 

        70         80         90        100        110        120 
VRSESIEEFV AALERPRRVL IMVKAGDPTD AVINELADAM EQGDIIIDGG NSLYTDTIRR 

       130        140        150        160        170        180 
EKAMADRGLH FVGAGISGGE EGALNGPSIM PGGPKKSYES LGPLLEEISA HVDGVPCCTH 

       190        200        210        220        230        240 
IGPDGSGHFV KMVHNGIEYS DMQLIGEAYQ LLRDGLGMSA PQIADVFTAW NKGELESYLI 

       250        260        270        280        290        300 
EITAEVLKQV DAKTGKPLVD VIVDAAEQKG TGRWTVKSAL DLGVPVTGIA EAVFARALSG 

       310        320        330        340        350        360 
SKPQRAASVG FASGQLGEKP SDAKQFVEDV RQALYASKIV AYAQGFNQIA AGSAEYGWNV 

       370        380        390        400        410        420 
SPGDLATIWR GGCIIRAQFL NRVKEAFADR PDLATLIAAP YFRDAVEKGI DSWRRVVVTA 

       430        440        450        460        470        480 
TQLGIPVPGF ASSLSYYDGL RTDRLPAALT QAQRDFFGAH TYERIDAPGK FHTLWSGDRN 


EVEA

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References

[1]"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
Genoscope
Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU458896 Genomic DNA. Translation: CAM62494.1.
RefSeqYP_001703148.1. NC_010397.1.

3D structure databases

ProteinModelPortalB1MB73.
SMRB1MB73. Positions 11-479.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1MB73.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000008853; EBMYCP00000008792; EBMYCG00000008851.
GeneID5964923.
GenomeReviewsGene locus MAB_2413c in contig CU458896_GR.
KEGGmab:MAB_2413c.
PATRIC17976560. VBIMycAbs55940_2457.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000015862.
HOGENOMHBG286913.
OMAMEHNEMA.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1MB73_MYCA9
AccessionPrimary (citable) accession number: B1MB73
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info