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B1MB69

- MASZ_MYCA9

UniProt

B1MB69 - MASZ_MYCA9

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Protein
Malate synthase G
Gene
glcB, MAB_2409c
Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei281 – 2811Acetyl-CoA By similarity
Binding sitei318 – 3181Acetyl-CoA By similarity
Active sitei346 – 3461Proton acceptor By similarity
Binding sitei346 – 3461Glyoxylate By similarity
Metal bindingi441 – 4411Magnesium By similarity
Binding sitei441 – 4411Glyoxylate By similarity
Metal bindingi469 – 4691Magnesium By similarity
Binding sitei550 – 5501Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei641 – 6411Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMABS36809-WGS:GSQO-2423-MONOMER.
MABS561007:GJTG-2423-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:MAB_2409c
OrganismiMycobacterium abscessus (strain ATCC 19977 / DSM 44196)
Taxonomic identifieri561007 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium abscessus
ProteomesiUP000007137: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Malate synthase GUniRule annotation
PRO_1000130892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei627 – 6271Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi561007.MAB_2409c.

Structurei

3D structure databases

ProteinModelPortaliB1MB69.
SMRiB1MB69. Positions 5-735.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA binding By similarity
Regioni466 – 4694Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

B1MB69-1 [UniParc]FASTAAdd to Basket

« Hide

MSDRVDVGNL RVARVLYDFI TNEALPGTGV DADAFWAGVD KVVTDLAPRN    50
RELLERRDDL QTQVDRWHRQ RAIEPLDGAA YQDFLTEIGY LVPEPEDFTI 100
TTANVDDEIT TTAGPQLVVP ILNARFALNA ANARWGSLYD ALYGTDVIPE 150
ADGAEKASAD TGGYNKVRGD KVIAYAREVL DGAAPLASGS WKDAVGLKID 200
DGQLLVELGD EFSTGLQNPD QFVGYTGKLG KPQWSVLLIN HGLHIEVLID 250
PDSPIGSTDK AGIKDVVLES AITTIMDFED SVAAVDAEDK VLGYRNWLGL 300
NKGDLSEEVS KGGKTFTRVL NEDRVFTTPD GKGELTLPGR SLLFVRNVGH 350
LMTNDAIVDA AGNEMPEGIQ DALFTSLIAI HGLRSGKKNG PLKNSRTGSI 400
YIVKPKMHGP EEVAFTAELF GRVEEVLGLP HATLKVGIMD EERRTTVNLK 450
AAIKAASDRV VFINTGFLDR TGDEIHTSME AGPMCRKAVM KSQPWILAYE 500
DHNVDTGLGA GLAGKAQIGK GMWAMPDLMA DMVAQKIAQP RAGATTAWVP 550
SPTAATLHAL HYHQVDVKAV DQELAGKHRA KLESLLTIPL AESRHDWTAE 600
DIREEIDNNC QSILGYVVRW IDQGVGCSKV PDIHDVALME DRATLRISSQ 650
LLANWLRHDV ITEDEVVEGL KRMAPVVDRQ NAGDKEYRPM APDFDSNIAF 700
QAAKELILEG KDQPNGYTEP ILHRRRREYK AAAAK 735
Length:735
Mass (Da):80,389
Last modified:April 29, 2008 - v1
Checksum:i29D2078E5D4D336E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU458896 Genomic DNA. Translation: CAM62490.1.
RefSeqiYP_001703144.1. NC_010397.1.

Genome annotation databases

EnsemblBacteriaiCAM62490; CAM62490; MAB_2409c.
GeneIDi5964919.
KEGGimab:MAB_2409c.
PATRICi17976552. VBIMycAbs55940_2453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU458896 Genomic DNA. Translation: CAM62490.1 .
RefSeqi YP_001703144.1. NC_010397.1.

3D structure databases

ProteinModelPortali B1MB69.
SMRi B1MB69. Positions 5-735.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561007.MAB_2409c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM62490 ; CAM62490 ; MAB_2409c .
GeneIDi 5964919.
KEGGi mab:MAB_2409c.
PATRICi 17976552. VBIMycAbs55940_2453.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci MABS36809-WGS:GSQO-2423-MONOMER.
MABS561007:GJTG-2423-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
    Genoscope
    Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19977 / DSM 44196.

Entry informationi

Entry nameiMASZ_MYCA9
AccessioniPrimary (citable) accession number: B1MB69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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