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B1MB69

- MASZ_MYCA9

UniProt

B1MB69 - MASZ_MYCA9

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Protein

Malate synthase G

Gene

glcB

Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei281 – 2811Acetyl-CoAUniRule annotation
Binding sitei318 – 3181Acetyl-CoAUniRule annotation
Active sitei346 – 3461Proton acceptorUniRule annotation
Binding sitei346 – 3461GlyoxylateUniRule annotation
Metal bindingi441 – 4411MagnesiumUniRule annotation
Binding sitei441 – 4411GlyoxylateUniRule annotation
Metal bindingi469 – 4691MagnesiumUniRule annotation
Binding sitei550 – 5501Acetyl-CoA; via carbonyl oxygenUniRule annotation
Active sitei641 – 6411Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMABS36809-WGS:GSQO-2423-MONOMER.
MABS561007:GJTG-2423-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:MAB_2409c
OrganismiMycobacterium abscessus (strain ATCC 19977 / DSM 44196)
Taxonomic identifieri561007 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium abscessus
ProteomesiUP000007137: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Malate synthase GPRO_1000130892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei627 – 6271Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi561007.MAB_2409c.

Structurei

3D structure databases

ProteinModelPortaliB1MB69.
SMRiB1MB69. Positions 5-735.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
Regioni466 – 4694Glyoxylate bindingUniRule annotation

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

B1MB69-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDRVDVGNL RVARVLYDFI TNEALPGTGV DADAFWAGVD KVVTDLAPRN
60 70 80 90 100
RELLERRDDL QTQVDRWHRQ RAIEPLDGAA YQDFLTEIGY LVPEPEDFTI
110 120 130 140 150
TTANVDDEIT TTAGPQLVVP ILNARFALNA ANARWGSLYD ALYGTDVIPE
160 170 180 190 200
ADGAEKASAD TGGYNKVRGD KVIAYAREVL DGAAPLASGS WKDAVGLKID
210 220 230 240 250
DGQLLVELGD EFSTGLQNPD QFVGYTGKLG KPQWSVLLIN HGLHIEVLID
260 270 280 290 300
PDSPIGSTDK AGIKDVVLES AITTIMDFED SVAAVDAEDK VLGYRNWLGL
310 320 330 340 350
NKGDLSEEVS KGGKTFTRVL NEDRVFTTPD GKGELTLPGR SLLFVRNVGH
360 370 380 390 400
LMTNDAIVDA AGNEMPEGIQ DALFTSLIAI HGLRSGKKNG PLKNSRTGSI
410 420 430 440 450
YIVKPKMHGP EEVAFTAELF GRVEEVLGLP HATLKVGIMD EERRTTVNLK
460 470 480 490 500
AAIKAASDRV VFINTGFLDR TGDEIHTSME AGPMCRKAVM KSQPWILAYE
510 520 530 540 550
DHNVDTGLGA GLAGKAQIGK GMWAMPDLMA DMVAQKIAQP RAGATTAWVP
560 570 580 590 600
SPTAATLHAL HYHQVDVKAV DQELAGKHRA KLESLLTIPL AESRHDWTAE
610 620 630 640 650
DIREEIDNNC QSILGYVVRW IDQGVGCSKV PDIHDVALME DRATLRISSQ
660 670 680 690 700
LLANWLRHDV ITEDEVVEGL KRMAPVVDRQ NAGDKEYRPM APDFDSNIAF
710 720 730
QAAKELILEG KDQPNGYTEP ILHRRRREYK AAAAK
Length:735
Mass (Da):80,389
Last modified:April 29, 2008 - v1
Checksum:i29D2078E5D4D336E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU458896 Genomic DNA. Translation: CAM62490.1.
RefSeqiYP_001703144.1. NC_010397.1.

Genome annotation databases

EnsemblBacteriaiCAM62490; CAM62490; MAB_2409c.
GeneIDi5964919.
KEGGimab:MAB_2409c.
PATRICi17976552. VBIMycAbs55940_2453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU458896 Genomic DNA. Translation: CAM62490.1 .
RefSeqi YP_001703144.1. NC_010397.1.

3D structure databases

ProteinModelPortali B1MB69.
SMRi B1MB69. Positions 5-735.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561007.MAB_2409c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM62490 ; CAM62490 ; MAB_2409c .
GeneIDi 5964919.
KEGGi mab:MAB_2409c.
PATRICi 17976552. VBIMycAbs55940_2453.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci MABS36809-WGS:GSQO-2423-MONOMER.
MABS561007:GJTG-2423-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
    Genoscope
    Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19977 / DSM 44196.

Entry informationi

Entry nameiMASZ_MYCA9
AccessioniPrimary (citable) accession number: B1MB69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3