B1MB03 (ARLY_MYCA9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	MAB_2343

Organism

Mycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]

Taxonomic identifier

561007 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Argininosuccinate lyase HAMAP MF_00006		PRO_1000089096

Sequences

	Sequence		Length	Mass (Da)
	B1MB03 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 6B0C6B0B5ECDF4C8	FASTA	473	50,270
	10 20 30 40 50 60 MSTNEGSLWG GRFAGGPAPA LAALSKSTHF DWALAPYDIQ ASVAHARVLR KAGLLTDEQL 70 80 90 100 110 120 GALVEGLEQL GRDVASGVFV PADTDEDVHG ALERGLIERV GPDIGGRLRA GRSRNDQVAT 130 140 150 160 170 180 LFRMWLRDAA GRISEGVLDV VQALADQAGA HPDAIMPGKT HLQAAQPVLL AHHLLAHAQP 190 200 210 220 230 240 LLRDVDRLVD WDRRTAVSPY GAGALAGSSL GLDPDAIALD LGFTAAADNS IDATSSRDFA 250 260 270 280 290 300 AEAGFVFAMI GIDLSRLSED IILWGTTEFG YVTLDDSWST GSSIMPQKKN PDIAELARGK 310 320 330 340 350 360 TGRLIGNLTG LLATLKAQPL AYNRDLQEDK EPLFDSVSQL ELLLPAMAGL VATLRFHTER 370 380 390 400 410 420 MAQLAPAGFT LATDLAEWMV RQGIPFRVAH EAAGEAVRVA EARGVGLEDL TDEEFAAIHP 430 440 450 460 470 ELTGDVRAVL TTAGSVASRD ARGGTAPERV AEQRELVLAR LNVLRGQNGR HPG

References

[1]

"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus." Genoscope Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19977 / DSM 44196.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU458896 Genomic DNA. Translation: CAM62424.1.
RefSeq	YP_001703078.1. NC_010397.1.
3D structure databases
ProteinModelPortal	B1MB03.
ModBase	Search...
Protein-protein interaction databases
STRING	B1MB03.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000007826; EBMYCP00000007765; EBMYCG00000007824.
GeneID	5964853.
GenomeReviews	Gene locus MAB_2343 in contig CU458896_GR.
KEGG	mab:MAB_2343.
PATRIC	17976416. VBIMycAbs55940_2386.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016253.
HOGENOM	HBG539632.
OMA	MPGRTHL.
Enzyme and pathway databases
BioCyc	MABS561007:MAB_2343-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_MYCA9

Accession

Primary (citable) accession number: B1MB03

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program