B1MAZ6 (ARGC_MYCA9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	MAB_2336

Organism

Mycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]

Taxonomic identifier

561007 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000096730
Sites
	Active site	153	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1MAZ6 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 8D522BAEB22544A1	FASTA	347	35,440
	10 20 30 40 50 60 MTTGFSVAVA GASGYAGGEI LRLLLAHPAY TAGRLRIGVL TAGSNAGSSL IEHHPNLTPL 70 80 90 100 110 120 ADHKLQPTDS TLLRGHDVVF LALPHGSSAK IAEELGPQTL IIDCGADFRL TDAAAWERYY 130 140 150 160 170 180 GSKHAGSWPY GLPELPGGRD ALHGTKRVAV PGCYPTAALL ALSPAVTAGL VEPSVTVVAV 190 200 210 220 230 240 SGTTGAGRAP KAELLASEVM GSARAYNIAG AHRHTPEIAQ GLKHPSGGPV SVSFTPVLIP 250 260 270 280 290 300 MPRGILATCT APTTASLSEI RDAYEDAYRT EEFIHVLPEG HLPTTKAVVG SNAVHIGLAV 310 320 330 340 DPDAGVLVAV AAIDNLVKGT AGAAIQSMNL ALGWPEADGL SIVGVAP

References

[1]

"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus." Genoscope Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19977 / DSM 44196.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU458896 Genomic DNA. Translation: CAM62417.1.
RefSeq	YP_001703071.1. NC_010397.1.
3D structure databases
ProteinModelPortal	B1MAZ6.
SMR	B1MAZ6. Positions 7-347.
ModBase	Search...
Protein-protein interaction databases
STRING	B1MAZ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000004602; EBMYCP00000004541; EBMYCG00000004600.
GeneID	5964846.
GenomeReviews	Gene locus MAB_2336 in contig CU458896_GR.
KEGG	mab:MAB_2336.
PATRIC	17976402. VBIMycAbs55940_2379.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015828.
HOGENOM	HBG294213.
OMA	SHFSWRN.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	MABS561007:MAB_2336-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_MYCA9

Accession

Primary (citable) accession number: B1MAZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program