ID   B1M6E8_METRJ            Unreviewed;       487 AA.
AC   B1M6E8;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Response regulator receiver modulated metal dependent phosphohydrolase {ECO:0000313|EMBL:ACB23608.1};
GN   OrderedLocusNames=Mrad2831_1613 {ECO:0000313|EMBL:ACB23608.1};
OS   Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS   NBRC 15690 / NCIMB 10815 / 0-1).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=426355 {ECO:0000313|EMBL:ACB23608.1, ECO:0000313|Proteomes:UP000006589};
RN   [1] {ECO:0000313|EMBL:ACB23608.1, ECO:0000313|Proteomes:UP000006589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 /
RC   0-1 {ECO:0000313|Proteomes:UP000006589};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT   2831.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001001; ACB23608.1; -; Genomic_DNA.
DR   RefSeq; WP_012318596.1; NC_010505.1.
DR   AlphaFoldDB; B1M6E8; -.
DR   STRING; 426355.Mrad2831_1613; -.
DR   KEGG; mrd:Mrad2831_1613; -.
DR   PATRIC; fig|426355.14.peg.1653; -.
DR   eggNOG; COG3437; Bacteria.
DR   HOGENOM; CLU_000445_92_10_5; -.
DR   OrthoDB; 9802066at2; -.
DR   Proteomes; UP000006589; Chromosome.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:UniProt.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR45228:SF1; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186; 1.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:ACB23608.1};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169}.
FT   DOMAIN          2..119
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000259|PROSITE:PS50110"
FT   DOMAIN          146..343
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   REGION          384..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..430
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         52
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   487 AA;  52387 MW;  2206E4140617EB91 CRC64;
     MDALLVDDSA TMRMRLRLLL EAKPDVSVTD HGDPVAAMVE ARTRAFDLVL VDCHMPGIDG
     IAFIRQMRTI PHYAQVPIVM VTSDISDAVR LAALEAGATD FLDKSMQGVE LTVRLRNLIR
     LARAVRRLAE QAAWLDGEVE AALRHMRERE EEIIFRLALA VEYRDNDTGD HTWRVARYSQ
     IVAEGLGLAP EICRNLYLAA PLHDVGKVGI PDGVLLKPGR LDRDEFDLVK THPAIGRRIL
     GGSASELIRL AAEIAEFHHE KWDGGGYPHG LAGAAIPLSA RIVAVADVFD ALTTARPYKD
     AMSFDAALDC IRAESGRHFD PDCVAAFCAR FPDIRVAGGQ NRAAVRPSAG PVTEPWARVP
     TLLREVTPAA PVPTGWRADA LDTLLRPSPE SSPAPSANPD AFAPLIPDPH GSRTEPDHDP
     DLEDAAGDRP GARDLPGGCP APRGRGELPE GVPRGRHRLP HLSPSRPGAP VAGASHAGAP
     RESVPGG
//