B1M3E0 (KHSE_METRJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Mrad2831_4313

Organism

Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831) [Complete proteome] [HAMAP]

Taxonomic identifier

426355 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Homoserine kinase HAMAP MF_00301		PRO_1000115434

Sequences

	Sequence		Length	Mass (Da)
	B1M3E0 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: A9C4570E25A8DC21	FASTA	321	35,192
	10 20 30 40 50 60 MAVYTEVSDA ALAEFLSAYA IGSLLSFKGI AEGVENSNFF LHTTEGAYIL TLYEKRVREQ 70 80 90 100 110 120 DLPFFIGLME HLSARGLACP QPVRDRAGQA LGQLCGRPAA IVSFLEGVSV KAPGAEHCRE 130 140 150 160 170 180 LGRALAELHA AGRDFPMVRE NNLSVSAWRP LFAQAEAQAD SVEPGLAART RSDLAVLEAH 190 200 210 220 230 240 WPRDLPGGVI HADLFTDNVF FIGDALSGLI DFYFACTDAF AYDLAVCLNA WCFDPDGTFH 250 260 270 280 290 300 RDMAAALIAG YEAVRPLEAA EVAALPILCR GAALRFMLTR LVDWLNVPPG ALVKPKDPRE 310 320 FDRRLTFHRQ ARDARDYGRP H

References

[1]

"Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Marx C.J., Richardson P. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27329 / DSM 1819 / JCM 2831.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001001 Genomic DNA. Translation: ACB26280.1.
RefSeq	YP_001756963.1. NC_010505.1.
3D structure databases
ProteinModelPortal	B1M3E0.
SMR	B1M3E0. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	B1M3E0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6140372.
GenomeReviews	Gene locus Mrad2831_4313 in contig CP001001_GR.
KEGG	mrd:Mrad2831_4313.
PATRIC	22577042. VBIMetRad70578_4390.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	CLSK2331237.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_METRJ

Accession

Primary (citable) accession number: B1M3E0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program