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B1M3C5

- B1M3C5_METRJ

UniProt

B1M3C5 - B1M3C5_METRJ

Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotation

    Catalytic activityi

    Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei93 – 931SubstrateUniRule annotation
    Sitei93 – 931Transition state stabilizerUniRule annotation
    Binding sitei172 – 1721SubstrateUniRule annotation
    Binding sitei227 – 2271SubstrateUniRule annotation
    Binding sitei370 – 3701SubstrateUniRule annotation

    GO - Molecular functioni

    1. uroporphyrinogen decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Biological processi

    Porphyrin biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciMRAD426355:GJB5-4347-MONOMER.
    UniPathwayiUPA00251; UER00321.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
    Short name:
    UPDUniRule annotation
    Short name:
    URO-DUniRule annotation
    Gene namesi
    Name:hemEUniRule annotation
    Ordered Locus Names:Mrad2831_4298Imported
    OrganismiMethylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)Imported
    Taxonomic identifieri426355 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000006589: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi426355.Mrad2831_4298.

    Structurei

    3D structure databases

    ProteinModelPortaliB1M3C5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni43 – 475Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0407.
    HOGENOMiHOG000253896.
    KOiK01599.
    OMAiDCVALDN.
    OrthoDBiEOG6VXF6H.

    Family and domain databases

    HAMAPiMF_00218. URO_D.
    InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
    IPR000257. Uroporphyrinogen_deCOase.
    [Graphical view]
    PfamiPF01208. URO-D. 2 hits.
    [Graphical view]
    PROSITEiPS00906. UROD_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1M3C5-1 [UniParc]FASTAAdd to Basket

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    MGATMTGTER EPERETSGTT SERKVLRVLE GEAIGPPPAW MMRQAGRYLP    50
    EYRATRAEAG SFLDLCYSPD FAVEVTLQPI RRFGFDAAIL FSDILVVPHA 100
    LGQDVRFVEG EGPRLDPLDG RAAFARLREA GDPAVMSHLA PVFETVTRLR 150
    AELPGETTLL GFCGAPWTVA SYMIGGRGTP DLAPARALAE GDTALVDTLI 200
    DRLVAVQTEY LVRQLEAGAD AVQIFESHAG TLPLAVLAPG GTVEPVGDVA 250
    ESALPGAAAA DALTRWSLRP IARMVAGVRA RVPGAKIIVF ARGSGLDGHA 300
    RVVPETGADA VGVDWGVDLK ALRQTVPAAT VTQGNLHPET LIAGGAALDA 350
    AVDAVLEATA GLPHIFNLGH GITPQTPVAH VERMLARLRG QG 392
    Length:392
    Mass (Da):41,212
    Last modified:April 29, 2008 - v1
    Checksum:iF69048E09322C61B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001001 Genomic DNA. Translation: ACB26265.1.
    RefSeqiWP_012321219.1. NC_010505.1.
    YP_001756948.1. NC_010505.1.

    Genome annotation databases

    EnsemblBacteriaiACB26265; ACB26265; Mrad2831_4298.
    GeneIDi6140357.
    KEGGimrd:Mrad2831_4298.
    PATRICi22577012. VBIMetRad70578_4375.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001001 Genomic DNA. Translation: ACB26265.1 .
    RefSeqi WP_012321219.1. NC_010505.1.
    YP_001756948.1. NC_010505.1.

    3D structure databases

    ProteinModelPortali B1M3C5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 426355.Mrad2831_4298.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB26265 ; ACB26265 ; Mrad2831_4298 .
    GeneIDi 6140357.
    KEGGi mrd:Mrad2831_4298.
    PATRICi 22577012. VBIMetRad70578_4375.

    Phylogenomic databases

    eggNOGi COG0407.
    HOGENOMi HOG000253896.
    KOi K01599.
    OMAi DCVALDN.
    OrthoDBi EOG6VXF6H.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00321 .
    BioCyci MRAD426355:GJB5-4347-MONOMER.

    Family and domain databases

    HAMAPi MF_00218. URO_D.
    InterProi IPR006361. Uroporphyrinogen_deCO2ase_HemE.
    IPR000257. Uroporphyrinogen_deCOase.
    [Graphical view ]
    Pfami PF01208. URO-D. 2 hits.
    [Graphical view ]
    PROSITEi PS00906. UROD_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Marx C.J., Richardson P.
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27329 / DSM 1819 / JCM 2831Imported.

    Entry informationi

    Entry nameiB1M3C5_METRJ
    AccessioniPrimary (citable) accession number: B1M3C5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3