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Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotation

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931SubstrateUniRule annotation
Sitei93 – 931Transition state stabilizerUniRule annotation
Binding sitei172 – 1721SubstrateUniRule annotation
Binding sitei227 – 2271SubstrateUniRule annotation
Binding sitei370 – 3701SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciMRAD426355:GJB5-4347-MONOMER.
UniPathwayiUPA00251; UER00321.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
Short name:
UPDUniRule annotation
Short name:
URO-DUniRule annotation
Gene namesi
Name:hemEUniRule annotation
Ordered Locus Names:Mrad2831_4298Imported
OrganismiMethylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)Imported
Taxonomic identifieri426355 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000006589 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi426355.Mrad2831_4298.

Structurei

3D structure databases

ProteinModelPortaliB1M3C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 475Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0407.
HOGENOMiHOG000253896.
KOiK01599.
OMAiFIDACFR.
OrthoDBiEOG6VXF6H.

Family and domain databases

HAMAPiMF_00218. URO_D.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 2 hits.
[Graphical view]
PROSITEiPS00906. UROD_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1M3C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGATMTGTER EPERETSGTT SERKVLRVLE GEAIGPPPAW MMRQAGRYLP
60 70 80 90 100
EYRATRAEAG SFLDLCYSPD FAVEVTLQPI RRFGFDAAIL FSDILVVPHA
110 120 130 140 150
LGQDVRFVEG EGPRLDPLDG RAAFARLREA GDPAVMSHLA PVFETVTRLR
160 170 180 190 200
AELPGETTLL GFCGAPWTVA SYMIGGRGTP DLAPARALAE GDTALVDTLI
210 220 230 240 250
DRLVAVQTEY LVRQLEAGAD AVQIFESHAG TLPLAVLAPG GTVEPVGDVA
260 270 280 290 300
ESALPGAAAA DALTRWSLRP IARMVAGVRA RVPGAKIIVF ARGSGLDGHA
310 320 330 340 350
RVVPETGADA VGVDWGVDLK ALRQTVPAAT VTQGNLHPET LIAGGAALDA
360 370 380 390
AVDAVLEATA GLPHIFNLGH GITPQTPVAH VERMLARLRG QG
Length:392
Mass (Da):41,212
Last modified:April 29, 2008 - v1
Checksum:iF69048E09322C61B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001001 Genomic DNA. Translation: ACB26265.1.
RefSeqiWP_012321219.1. NC_010505.1.
YP_001756948.1. NC_010505.1.

Genome annotation databases

EnsemblBacteriaiACB26265; ACB26265; Mrad2831_4298.
KEGGimrd:Mrad2831_4298.
PATRICi22577012. VBIMetRad70578_4375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001001 Genomic DNA. Translation: ACB26265.1.
RefSeqiWP_012321219.1. NC_010505.1.
YP_001756948.1. NC_010505.1.

3D structure databases

ProteinModelPortaliB1M3C5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426355.Mrad2831_4298.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB26265; ACB26265; Mrad2831_4298.
KEGGimrd:Mrad2831_4298.
PATRICi22577012. VBIMetRad70578_4375.

Phylogenomic databases

eggNOGiCOG0407.
HOGENOMiHOG000253896.
KOiK01599.
OMAiFIDACFR.
OrthoDBiEOG6VXF6H.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00321.
BioCyciMRAD426355:GJB5-4347-MONOMER.

Family and domain databases

HAMAPiMF_00218. URO_D.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 2 hits.
[Graphical view]
PROSITEiPS00906. UROD_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marx C.J., Richardson P.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27329 / DSM 1819 / JCM 2831Imported.

Entry informationi

Entry nameiB1M3C5_METRJ
AccessioniPrimary (citable) accession number: B1M3C5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 27, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.