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B1M3C5 (B1M3C5_METRJ) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP-Rule MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP-Rule MF_00218

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP-Rule MF_00218

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00218

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP-Rule MF_00218

Ontologies

Keywords
   Biological processPorphyrin biosynthesis HAMAP-Rule MF_00218
   Cellular componentCytoplasm HAMAP-Rule MF_00218
   Molecular functionDecarboxylase HAMAP-Rule MF_00218
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region43 – 475Substrate binding By similarity HAMAP-Rule MF_00218

Sites

Binding site931Substrate By similarity HAMAP-Rule MF_00218
Binding site1721Substrate By similarity HAMAP-Rule MF_00218
Binding site2271Substrate By similarity HAMAP-Rule MF_00218
Binding site3701Substrate By similarity HAMAP-Rule MF_00218
Site931Transition state stabilizer By similarity HAMAP-Rule MF_00218

Sequences

Sequence LengthMass (Da)Tools
B1M3C5 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: F69048E09322C61B

FASTA39241,212
        10         20         30         40         50         60 
MGATMTGTER EPERETSGTT SERKVLRVLE GEAIGPPPAW MMRQAGRYLP EYRATRAEAG 

        70         80         90        100        110        120 
SFLDLCYSPD FAVEVTLQPI RRFGFDAAIL FSDILVVPHA LGQDVRFVEG EGPRLDPLDG 

       130        140        150        160        170        180 
RAAFARLREA GDPAVMSHLA PVFETVTRLR AELPGETTLL GFCGAPWTVA SYMIGGRGTP 

       190        200        210        220        230        240 
DLAPARALAE GDTALVDTLI DRLVAVQTEY LVRQLEAGAD AVQIFESHAG TLPLAVLAPG 

       250        260        270        280        290        300 
GTVEPVGDVA ESALPGAAAA DALTRWSLRP IARMVAGVRA RVPGAKIIVF ARGSGLDGHA 

       310        320        330        340        350        360 
RVVPETGADA VGVDWGVDLK ALRQTVPAAT VTQGNLHPET LIAGGAALDA AVDAVLEATA 

       370        380        390 
GLPHIFNLGH GITPQTPVAH VERMLARLRG QG 

« Hide

References

[1]"Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Marx C.J., Richardson P.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27329 / DSM 1819 / JCM 2831.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001001 Genomic DNA. Translation: ACB26265.1.
RefSeqYP_001756948.1. NC_010505.1.

3D structure databases

ProteinModelPortalB1M3C5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING426355.Mrad2831_4298.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB26265; ACB26265; Mrad2831_4298.
GeneID6140357.
KEGGmrd:Mrad2831_4298.
PATRIC22577012. VBIMetRad70578_4375.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHOG000253896.
KOK01599.
OMADCVALDN.
OrthoDBEOG6VXF6H.

Enzyme and pathway databases

BioCycMRAD426355:GJB5-4347-MONOMER.
UniPathwayUPA00251; UER00321.

Family and domain databases

HAMAPMF_00218. URO_D.
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamPF01208. URO-D. 2 hits.
[Graphical view]
PROSITEPS00906. UROD_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1M3C5_METRJ
AccessionPrimary (citable) accession number: B1M3C5
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)