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B1M3B2 (AROE_METRJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate dehydrogenase
EC=1.1.1.25
Gene names
Name:aroE
Ordered Locus Names:Mrad2831_4285
OrganismMethylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831) [Complete proteome] [HAMAP]
Taxonomic identifier426355 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

shikimate 3-dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Shikimate dehydrogenase HAMAP MF_00222
PRO_1000118879

Regions

Nucleotide binding134 – 1385NADP By similarity

Sites

Active site691Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
B1M3B2 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 3C565D7482CE0820

FASTA28228,926
        10         20         30         40         50         60 
MSVATPRAFV VGHPIAHSRS PLIHGHWLAV HGIPGSYERL DVPPAAFPDF VRGLPDSGFR 

        70         80         90        100        110        120 
GGNVTIPHKE AAFALADTLT PRARAIGAVN TLVVGPDGRI RGDNTDAPGF CAHLDHSLGA 

       130        140        150        160        170        180 
AWPERAGGTA LVLGAGGAAR AVVVGLAERG LRRVWVANRT AARAEAVAAL APGVGAALAW 

       190        200        210        220        230        240 
DDLPAALPGT GLLVNTTSLG MKGQPPLAVD LSPLPADAAV ADIVYAPLET ALLAAARRRG 

       250        260        270        280 
LAAVDGLGML LHQAVPGFEA WFGPRPRVTP ELRDRIVADL AG

« Hide

References

[1]"Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Marx C.J., Richardson P.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27329 / DSM 1819 / JCM 2831.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001001 Genomic DNA. Translation: ACB26252.1.
RefSeqYP_001756935.1. NC_010505.1.

3D structure databases

ProteinModelPortalB1M3B2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1M3B2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6140344.
GenomeReviewsGene locus Mrad2831_4285 in contig CP001001_GR.
KEGGmrd:Mrad2831_4285.
PATRIC22576986. VBIMetRad70578_4362.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG553408.
OMALHLKTHG.
ProtClustDBCLSK2330698.

Family and domain databases

HAMAPMF_00222. Shikimate_DH_AroE.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00014.
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00507. AroE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROE_METRJ
AccessionPrimary (citable) accession number: B1M3B2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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