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B1M0D1

- FTHS_METRJ

UniProt

B1M0D1 - FTHS_METRJ

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Mrad2831_4072
Organism
Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMRAD426355:GJB5-4120-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Mrad2831_4072
OrganismiMethylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)
Taxonomic identifieri426355 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000006589: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000196816Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi426355.Mrad2831_4072.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1M0D1-1 [UniParc]FASTAAdd to Basket

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MPSDIEIARA ATLKPIAQVA EKLGIPDDAL HNYGKHIAKI DHGYIAGLES    50
RKPGKLVLVT AISPTPAGEG KTTTTVGLGD ALNRIGEKTM ICLREPSLGP 100
CFGMKGGAAG GGKAQVVPME QINLHFTGDF HAITSAHSLA AALIDNHVYW 150
ANELNIDVRR IHWRRVVDMN DRALRAITQS LGGVANGFPR EDGFDITVAS 200
EVMAVFCLAK DLADLEERLG RIVIAETRDR KLVTLKDVKA TGAMTVLLKD 250
ALQPNLVQTL EGNPALIHGG PFANIAHGCN SVIATRAGLR LADYTVTEAG 300
FGADLGAEKF LDIKCRQAGL TPSAVVVVAT IRALKMHGGV DKKNLGAENI 350
DALEKGFANL ARHVTNLRGF GLPVVVGVNH FHADTEAEHA KLKELCRERL 400
DVEAITCRHW AEGGAGAEEL ARAVVKLSQA EPAPIRHAYE TESRLTDKIR 450
AIATKLYGAA DIQIETKAAG KLATFEKDGY GHLPICMAKT QYSFSTDPTL 500
MGAPEGHIVG VRDVRLSAGA GFVVAICGEI MTMPGLPRVP AADTIRLDAN 550
GQIDGLF 557
Length:557
Mass (Da):59,349
Last modified:April 29, 2008 - v1
Checksum:i809722BF98FD83CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001001 Genomic DNA. Translation: ACB26042.1.
RefSeqiYP_001756725.1. NC_010505.1.

Genome annotation databases

EnsemblBacteriaiACB26042; ACB26042; Mrad2831_4072.
GeneIDi6140130.
KEGGimrd:Mrad2831_4072.
PATRICi22576588. VBIMetRad70578_4164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001001 Genomic DNA. Translation: ACB26042.1 .
RefSeqi YP_001756725.1. NC_010505.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 426355.Mrad2831_4072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB26042 ; ACB26042 ; Mrad2831_4072 .
GeneIDi 6140130.
KEGGi mrd:Mrad2831_4072.
PATRICi 22576588. VBIMetRad70578_4164.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MRAD426355:GJB5-4120-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marx C.J., Richardson P.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27329 / DSM 1819 / JCM 2831.

Entry informationi

Entry nameiFTHS_METRJ
AccessioniPrimary (citable) accession number: B1M0D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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