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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi487MagnesiumUniRule annotation1
Metal bindingi493MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Mrad2831_0939
OrganismiMethylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1)
Taxonomic identifieri426355 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000006589 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001479311 – 739Polyribonucleotide nucleotidyltransferaseAdd BLAST739

Proteomic databases

PRIDEiB1LZQ1

Interactioni

Protein-protein interaction databases

STRINGi426355.Mrad2831_0939

Structurei

3D structure databases

ProteinModelPortaliB1LZQ1
SMRiB1LZQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini554 – 613KHUniRule annotationAdd BLAST60
Domaini623 – 691S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

B1LZQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDVQREELM WGDRKLVLET GKVARQADGA VIATYGETSV LATVVAAKEP
60 70 80 90 100
KPGIDFMPLT VNYQERAYAA GRIPGGYFKR EGRPSEKETL VSRLIDRPIR
110 120 130 140 150
PLFIEGWRND TQVVVTVLTH DLENDPDIVA MVAASAALTL SGVPFMGPIG
160 170 180 190 200
GARVGYINGG YRLNPLVTET KEESSLDLVV AGTQDAVLMV ESEAKELSED
210 220 230 240 250
VMLGAVMFGH KHFQPVIEAI IRLAEKAAKE PRDFKAPENA DVEKAVLEVC
260 270 280 290 300
EAELRAAYTK TVKQERYAAV DAVKAKVMAA LCPEGAEKFP AEKVKAAFKE
310 320 330 340 350
AQSKVVRWNI LDSGARIDGR DVKTVRSILS EVGVLPRAHG SALFTRGETQ
360 370 380 390 400
ALVVATLGTG EDEQFIDALE GTYKERFLLH YNFPPYSVGE TGRMGSPGRR
410 420 430 440 450
EIGHGKLAWR AIRPVLPPAH EFPYTIRVVS EITESNGSSS MASVCGGSLS
460 470 480 490 500
LMDAGVPLRR PVAGIAMGLI LEGERFAVLS DILGDEDHLG DMDFKVAGTD
510 520 530 540 550
EGVTSLQMDI KIAGITEEIM KIALAQAKDG RAHILAEMAK ALTAARPELG
560 570 580 590 600
EYAPRIETMQ IPTDKIRDVI GTGGKVIREI VEKTGAKINI EDTGVVKIAS
610 620 630 640 650
ADGKAIKAAY NWIRSIVAEP EVGVIYDGTI VKCMEFGAFV NFFGAKDGLV
660 670 680 690 700
HISELAAQRV AKVQDVVKEG DKVKVKFLGQ DDRGKIRLSM KVVDQQTGED
710 720 730
ITDKIKAQRD AERAERGDEP REPREGGRHR GERRREAGE
Length:739
Mass (Da):80,455
Last modified:April 29, 2008 - v1
Checksum:i0E6293D77C0FD3DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001001 Genomic DNA Translation: ACB22949.1
RefSeqiWP_012317942.1, NC_010505.1

Genome annotation databases

EnsemblBacteriaiACB22949; ACB22949; Mrad2831_0939
GeneIDi6136956
KEGGimrd:Mrad2831_0939

Entry informationi

Entry nameiPNP_METRJ
AccessioniPrimary (citable) accession number: B1LZQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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