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B1LZA0

- B1LZA0_METRJ

UniProt

B1LZA0 - B1LZA0_METRJ

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 3

Gene

fabH

Organism
Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei128 – 1281UniRule annotation
    Active sitei262 – 2621UniRule annotation
    Active sitei292 – 2921UniRule annotation

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
    2. beta-ketoacyl-acyl-carrier-protein synthase III activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciMRAD426355:GJB5-4013-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 3UniRule annotation (EC:2.3.1.180UniRule annotation)
    Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase IIIUniRule annotation
    Beta-ketoacyl-ACP synthase IIIUniRule annotation
    Gene namesi
    Name:fabHUniRule annotation
    Ordered Locus Names:Mrad2831_3968Imported
    OrganismiMethylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)Imported
    Taxonomic identifieri426355 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000006589: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi426355.Mrad2831_3968.

    Structurei

    3D structure databases

    ProteinModelPortaliB1LZA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni263 – 2675ACP-bindingUniRule annotation

    Domaini

    The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.UniRule annotation

    Sequence similaritiesi

    Belongs to the FabH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0332.
    HOGENOMiHOG000246674.
    KOiK00648.
    OMAiHGFAFDM.
    OrthoDBiEOG6J74XN.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    HAMAPiMF_01815. FabH.
    InterProiIPR013751. ACP_syn_III.
    IPR013747. ACP_syn_III_C.
    IPR004655. FabH_synth.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF08545. ACP_syn_III. 1 hit.
    PF08541. ACP_syn_III_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 1 hit.
    TIGRFAMsiTIGR00747. fabH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1LZA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATLRTDPGQ HRRVPPLRSV VVGTGSSLPA RVVTNADLAE RVDTSDEWIV    50
    QRTGIRQRHL AGPDETTSVL GTRAARAALD DAGLTADDID LVICATSTPD 100
    HTFPATATQI QAALGIHQGA AFDLQAVCAG FVFAVSTADK FLTTGAARRA 150
    LVIGAETFSR IVDWEDRTTC VLFGDGAGAV VLEAQEGAGD RGVLSASLRS 200
    DGRHREKLYV DGGPGSTGTT GHLRMEGRDV FRFAVGQVTD VIVEAFAQAG 250
    ITAEELDWFV PHQANRRIIE ASADKLGVAR DKIVLTVDRH GNTSAASIPL 300
    ALDVARRDGR IRAGDLVMIE AIGGGFSWGA ALIRW 335
    Length:335
    Mass (Da):35,471
    Last modified:April 29, 2008 - v1
    Checksum:iF2251D22DA37780E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001001 Genomic DNA. Translation: ACB25942.1.
    RefSeqiYP_001756625.1. NC_010505.1.

    Genome annotation databases

    EnsemblBacteriaiACB25942; ACB25942; Mrad2831_3968.
    GeneIDi6140023.
    KEGGimrd:Mrad2831_3968.
    PATRICi22576382. VBIMetRad70578_4064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001001 Genomic DNA. Translation: ACB25942.1 .
    RefSeqi YP_001756625.1. NC_010505.1.

    3D structure databases

    ProteinModelPortali B1LZA0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 426355.Mrad2831_3968.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB25942 ; ACB25942 ; Mrad2831_3968 .
    GeneIDi 6140023.
    KEGGi mrd:Mrad2831_3968.
    PATRICi 22576382. VBIMetRad70578_4064.

    Phylogenomic databases

    eggNOGi COG0332.
    HOGENOMi HOG000246674.
    KOi K00648.
    OMAi HGFAFDM.
    OrthoDBi EOG6J74XN.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci MRAD426355:GJB5-4013-MONOMER.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    HAMAPi MF_01815. FabH.
    InterProi IPR013751. ACP_syn_III.
    IPR013747. ACP_syn_III_C.
    IPR004655. FabH_synth.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF08545. ACP_syn_III. 1 hit.
    PF08541. ACP_syn_III_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 1 hit.
    TIGRFAMsi TIGR00747. fabH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Marx C.J., Richardson P.
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27329 / DSM 1819 / JCM 2831Imported.

    Entry informationi

    Entry nameiB1LZA0_METRJ
    AccessioniPrimary (citable) accession number: B1LZA0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotation, Reference proteomeImported

    External Data

    Dasty 3