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Protein

NAD(P)H dehydrogenase (quinone)

Gene

Mrad2831_3831

Organism
Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121NAD(P)UniRule annotation
Binding sitei98 – 981SubstrateUniRule annotation
Binding sitei134 – 1341FMNUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 145FMNUniRule annotation
Nucleotide bindingi110 – 16253FMNUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMRAD426355:GJB5-3875-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H dehydrogenase (quinone)UniRule annotation (EC:1.6.5.2UniRule annotation)
Alternative name(s):
Flavoprotein WrbA
NAD(P)H:quinone oxidoreductaseUniRule annotation
Short name:
NQOUniRule annotation
Gene namesi
Ordered Locus Names:Mrad2831_3831
OrganismiMethylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)
Taxonomic identifieri426355 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000006589 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200NAD(P)H dehydrogenase (quinone)PRO_1000200635Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi426355.Mrad2831_3831.

Structurei

3D structure databases

ProteinModelPortaliB1LY35.
SMRiB1LY35. Positions 2-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 190187Flavodoxin-likeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the WrbA family.UniRule annotation
Contains 1 flavodoxin-like domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CS1. Bacteria.
COG0655. LUCA.
HOGENOMiHOG000030539.
KOiK03809.
OMAiWMKGALV.
OrthoDBiEOG6384K0.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1LY35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVLVLYYS TYGHVEQMAY AVAEGARETG AEVVVKRVPE LVPEEVARQN
60 70 80 90 100
HFKLDQAAPV ATVAELADYD AIIFGTPTRY GNMASQMKQF IDQTGGLWMK
110 120 130 140 150
GALVGKVGSV FTSTASQHGG QETTLTSFHT VLFHHGMVVV GLPYSFQGQA
160 170 180 190 200
GVEAVKGNTP YGASTIADGD GSRQPSAVEL EGARFQGRHV AGIAAKLARD
Length:200
Mass (Da):21,274
Last modified:April 29, 2008 - v1
Checksum:iB16D5801F08A62D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001001 Genomic DNA. Translation: ACB25806.1.
RefSeqiWP_012320764.1. NC_010505.1.

Genome annotation databases

EnsemblBacteriaiACB25806; ACB25806; Mrad2831_3831.
GeneIDi6139885.
KEGGimrd:Mrad2831_3831.
PATRICi22576090. VBIMetRad70578_3919.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001001 Genomic DNA. Translation: ACB25806.1.
RefSeqiWP_012320764.1. NC_010505.1.

3D structure databases

ProteinModelPortaliB1LY35.
SMRiB1LY35. Positions 2-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426355.Mrad2831_3831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB25806; ACB25806; Mrad2831_3831.
GeneIDi6139885.
KEGGimrd:Mrad2831_3831.
PATRICi22576090. VBIMetRad70578_3919.

Phylogenomic databases

eggNOGiENOG4105CS1. Bacteria.
COG0655. LUCA.
HOGENOMiHOG000030539.
KOiK03809.
OMAiWMKGALV.
OrthoDBiEOG6384K0.

Enzyme and pathway databases

BioCyciMRAD426355:GJB5-3875-MONOMER.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marx C.J., Richardson P.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27329 / DSM 1819 / JCM 2831.

Entry informationi

Entry nameiNQOR_METRJ
AccessioniPrimary (citable) accession number: B1LY35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: January 20, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.