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Protein

Superoxide dismutase [Cu-Zn]

Gene

Mrad2831_3819

Organism
Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciMRAD426355:GJB5-3863-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Mrad2831_3819Imported
OrganismiMethylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)Imported
Taxonomic identifieri426355 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000006589: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 PotentialImportedAdd
BLAST
Chaini23 – 179157 PotentialImportedPRO_5000318374Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi426355.Mrad2831_3819.

Structurei

3D structure databases

ProteinModelPortaliB1LY23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
KOiK04565.
OMAiGLHFHEK.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1LY23-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRTLPLLAL LGTAAAGGAL AQEPPKEAAK PAETYTAPIK NAKGDPIGTL
60 70 80 90 100
AIRDGANTLV LRVTIQPGGL PPGWHGMHFH AVGDCSDPKF MNSKAHVNHD
110 120 130 140 150
QSKHGLLNAE GPDEGDLPNL YAAQDGSANA EVSSETPLNG EGGLKDGDGA
160 170
ALIIHANEDD HNTQPIGGAG DRIACGVIK
Length:179
Mass (Da):18,316
Last modified:April 29, 2008 - v1
Checksum:i21C6EBD668D9E780
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001001 Genomic DNA. Translation: ACB25794.1.
RefSeqiYP_001756477.1. NC_010505.1.

Genome annotation databases

EnsemblBacteriaiACB25794; ACB25794; Mrad2831_3819.
GeneIDi6139873.
KEGGimrd:Mrad2831_3819.
PATRICi22576064. VBIMetRad70578_3906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001001 Genomic DNA. Translation: ACB25794.1.
RefSeqiYP_001756477.1. NC_010505.1.

3D structure databases

ProteinModelPortaliB1LY23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426355.Mrad2831_3819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB25794; ACB25794; Mrad2831_3819.
GeneIDi6139873.
KEGGimrd:Mrad2831_3819.
PATRICi22576064. VBIMetRad70578_3906.

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
KOiK04565.
OMAiGLHFHEK.
OrthoDBiEOG6K13RS.

Enzyme and pathway databases

BioCyciMRAD426355:GJB5-3863-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marx C.J., Richardson P.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27329 / DSM 1819 / JCM 2831Imported.

Entry informationi

Entry nameiB1LY23_METRJ
AccessioniPrimary (citable) accession number: B1LY23
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: January 7, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.