B1LXS4 (B1LXS4_METRJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut EMBL ACB24281.1
EC=3.6.1.23 EMBL ACB24281.1

Gene names

Ordered Locus Names:

Mrad2831_2286

Organism

Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831) [Complete proteome] [HAMAP]

Taxonomic identifier

426355 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. SAAS SAAS008181
Catalytic activity	dUTP + H2O = dUMP + diphosphate. SAAS SAAS008181
Cofactor	Magnesium By similarity. SAAS SAAS008181

Ontologies

Keywords
Biological process	Nucleotide metabolism SAAS SAAS008181
Ligand	Magnesium SAAS SAAS008181 Metal-binding SAAS SAAS008181
Molecular function	Hydrolase SAAS SAAS008181 EMBL ACB24281.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1LXS4 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 7D290486165112D8	FASTA	156	16,354
	10 20 30 40 50 60 MSDLPEVGLR LLDPRLPGWG FPRWGSSAAA GLDLHACLDA PVVLPPQGKP VLIPAGFTVL 70 80 90 100 110 120 IRDPAWCGLI FPRSGRGHRE GLVLGNGTGV IDADYEGPLM VSAWNRDASE PVRIEPGDRI 130 140 150 AQLVFTRVTR PALTVLEGAP GPGSERGAGG FGSSGR

References

[1]

"Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Marx C.J., Richardson P. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27329 / DSM 1819 / JCM 2831.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001001 Genomic DNA. Translation: ACB24281.1.
RefSeq	YP_001754964.1. NC_010505.1.
3D structure databases
ProteinModelPortal	B1LXS4.
ModBase	Search...
Protein-protein interaction databases
STRING	B1LXS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6138318.
GenomeReviews	Gene locus Mrad2831_2286 in contig CP001001_GR.
KEGG	mrd:Mrad2831_2286.
PATRIC	22572910. VBIMetRad70578_2350.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG436079.
OMA	LDLRACI.
ProtClustDB	CLSK2330713.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
KO	K01520.
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. Dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B1LXS4_METRJ

Accession

Primary (citable) accession number: B1LXS4

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)