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B1LXH9 (B1LXH9_METRJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323 RuleBase RU000607
EC=4.99.1.1 HAMAP MF_00323 RuleBase RU000607
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323
Ordered Locus Names:Mrad2831_0734
OrganismMethylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831) [Complete proteome] [HAMAP]
Taxonomic identifier426355 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323 RuleBase RU004185

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2301Iron By similarity HAMAP MF_00323
Metal binding3111Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
B1LXH9 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: A885ED39D81F5519

FASTA36040,674
        10         20         30         40         50         60 
MNERVEPAAL ANGRPLAPLQ PAANALPADH PKVAWGRVGV LLMNLGTPEG TSYWPMRRYL 

        70         80         90        100        110        120 
KEFLSDRRVI EVPRLIWWPL LNLIILTKRP GPKGRDYASV WNNALNEGPL KTITRGQCER 

       130        140        150        160        170        180 
LQAAMGESVV VDWAMRYGKP EVAGRIQALL DQGCDRILLV PLYPQYAAAT SATACDQAFR 

       190        200        210        220        230        240 
ALMDMRWQPT VRVSPPYHDD PVYIAAMADS IREGLAKLDF EPEVILTSFH GVPRSYLLKG 

       250        260        270        280        290        300 
DPYHCQCHKT GRLIREALGL SPEKMRVTFQ SRFGNEEWLK PYTDETVMEL AKSGVKRMAI 

       310        320        330        340        350        360 
VAPGFTADCL ETLEELDGEN RHYFEENGGE RFAYIPCLND SDLGMRVIEH VVRRELQGWI

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References

[1]"Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Marx C.J., Richardson P.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27329 / DSM 1819 / JCM 2831.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001001 Genomic DNA. Translation: ACB22745.1.
RefSeqYP_001753428.1. NC_010505.1.

3D structure databases

ProteinModelPortalB1LXH9.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1LXH9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6136749.
GenomeReviewsGene locus Mrad2831_0734 in contig CP001001_GR.
KEGGmrd:Mrad2831_0734.
PATRIC22569710. VBIMetRad70578_0766.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMAIRPAKSA.
ProtClustDBCLSK979865.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1LXH9_METRJ
AccessionPrimary (citable) accession number: B1LXH9
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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