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B1LXE7 (B1LXE7_METRJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase HAMAP MF_00219
Short name=DHOase HAMAP MF_00219
EC=3.5.2.3 HAMAP MF_00219
Gene names
Name:pyrC HAMAP MF_00219
Ordered Locus Names:Mrad2831_5321
OrganismMethylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831) [Complete proteome] [HAMAP]
Taxonomic identifier426355 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00219 RuleBase RU003440 SAAS SAAS004721

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00219 RuleBase RU003440 SAAS SAAS004721

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00219 RuleBase RU003440 SAAS SAAS004721

Subunit structure

Homodimer By similarity. HAMAP MF_00219 SAAS SAAS004721

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily. HAMAP MF_00219 RuleBase RU003440

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding291Zinc 1 By similarity HAMAP MF_00219
Metal binding311Zinc 1 By similarity HAMAP MF_00219
Metal binding1151Zinc 1; via carbamate group By similarity HAMAP MF_00219
Metal binding1151Zinc 2; via carbamate group By similarity HAMAP MF_00219
Metal binding1521Zinc 2 By similarity HAMAP MF_00219
Metal binding1901Zinc 2 By similarity HAMAP MF_00219
Metal binding2631Zinc 1 By similarity HAMAP MF_00219

Amino acid modifications

Modified residue1151N6-carboxylysine By similarity HAMAP MF_00219

Sequences

Sequence LengthMass (Da)Tools
B1LXE7 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 6C899795CB469EC9

FASTA35939,341
        10         20         30         40         50         60 
MGVAELFPAE RQEANPVDRI TIRRPDDWHI HLRDGAMLKA VLPYTAAQFA RGIIMPNLVP 

        70         80         90        100        110        120 
PVTTVAAAQA YRERILAALP EGQDFTPLMT CYLRDDTDPD EIERGFGEKV WVAAKLYPAG 

       130        140        150        160        170        180 
ATTNSHAGVT DLNGIAPVLE RMERIGMPLL IHGEATDPEI DIFDREAAFM EGSLIPLLGR 

       190        200        210        220        230        240 
HQGLKVTVEH ATTAEILDVV REHRSRCAAT ITPHHLVINR THIFQGGLRP HLYCLPVAKR 

       250        260        270        280        290        300 
ERHRLALRRA ATSGEACFYL GTDTAPHVRG AKEASCGCAG VFCGPSALQT YVQVFDEEGA 

       310        320        330        340        350 
LDKFEAFASL NGARFHGLEP NAGTVTLERR ESRIAEAVAV DDTAVVVFRG EETLPWSVA

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References

[1]"Complete sequence of chromosome of Methylobacterium radiotolerans JCM 2831."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Marx C.J., Richardson P.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27329 / DSM 1819 / JCM 2831.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001001 Genomic DNA. Translation: ACB27268.1.
RefSeqYP_001757951.1. NC_010505.1.

3D structure databases

ProteinModelPortalB1LXE7.
SMRB1LXE7. Positions 19-359.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1LXE7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6141393.
GenomeReviewsGene locus Mrad2831_5321 in contig CP001001_GR.
KEGGmrd:Mrad2831_5321.
PATRIC22579038. VBIMetRad70578_5375.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628648.
OMACLPVAKR.
ProtClustDBPRK05451.

Family and domain databases

HAMAPMF_00219. PyrC_type1.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. PyrC_dimer. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1LXE7_METRJ
AccessionPrimary (citable) accession number: B1LXE7
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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