ID   B1LVJ9_METRJ            Unreviewed;       345 AA.
AC   B1LVJ9;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   SubName: Full=Response regulator receiver modulated metal dependent phosphohydrolase {ECO:0000313|EMBL:ACB24080.1};
GN   OrderedLocusNames=Mrad2831_2085 {ECO:0000313|EMBL:ACB24080.1};
OS   Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS   NBRC 15690 / NCIMB 10815 / 0-1).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=426355 {ECO:0000313|EMBL:ACB24080.1, ECO:0000313|Proteomes:UP000006589};
RN   [1] {ECO:0000313|EMBL:ACB24080.1, ECO:0000313|Proteomes:UP000006589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 /
RC   0-1 {ECO:0000313|Proteomes:UP000006589};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT   2831.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001001; ACB24080.1; -; Genomic_DNA.
DR   RefSeq; WP_012319060.1; NC_010505.1.
DR   AlphaFoldDB; B1LVJ9; -.
DR   STRING; 426355.Mrad2831_2085; -.
DR   KEGG; mrd:Mrad2831_2085; -.
DR   PATRIC; fig|426355.14.peg.2142; -.
DR   eggNOG; COG3437; Bacteria.
DR   HOGENOM; CLU_000445_92_10_5; -.
DR   OrthoDB; 9802066at2; -.
DR   Proteomes; UP000006589; Chromosome.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:UniProt.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR45228:SF1; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186; 1.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:ACB24080.1};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169}.
FT   DOMAIN          2..121
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000259|PROSITE:PS50110"
FT   DOMAIN          148..345
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          170..294
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   345 AA;  37658 MW;  A1F152DADDD3118D CRC64;
     MLALILDDSE MNNLLIMQAL KPVADCEPVA FTCPVTALDF LRAHVDRIGV VVTDYDMPGL
     TGLEVIAAAR AIPGFAHVPI VMVTSLDQRS LRHEALRAGA TDFLGKPCDP VEIQARITNL
     MKISAAHRQE QDRAAWLARE VAAAVAVIEA REREIIALLM RAAEHRDTDT GDHIARVAGY
     VGVIARNLGF NPEEIRILKL ASTMHDVGKI GVPDAILLKP GPLSAEERAE MEKHAERGRR
     ILEGSTSDVV RLAAEIAESH HERWDGTGYP KGLRGEAIPL SGRIVAVADV FDALVTERPY
     KAAWPLERAR AFVADQSGRH FDPRCVEAFL AGWEAVTRTC LRAAA
//