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Protein

Glutaminase

Gene

glsA

Organism
Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64SubstrateUniRule annotation1
Binding sitei114SubstrateUniRule annotation1
Binding sitei160SubstrateUniRule annotation1
Binding sitei167SubstrateUniRule annotation1
Binding sitei191SubstrateUniRule annotation1
Binding sitei243SubstrateUniRule annotation1
Binding sitei261Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:Mrad2831_3529
OrganismiMethylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)
Taxonomic identifieri426355 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000006589 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001156981 – 309GlutaminaseAdd BLAST309

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi426355.Mrad2831_3529.

Structurei

3D structure databases

ProteinModelPortaliB1LUS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSV. Bacteria.
COG2066. LUCA.
HOGENOMiHOG000216890.
KOiK01425.
OMAiANYMKSF.
OrthoDBiPOG091H02PU.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

B1LUS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDLAHVIRE ISEEMAQRSD RGAVADYIPE LARVDPDQFG MAVIDAEGQV
60 70 80 90 100
FTGGDSETPF SIQSVSKVFT LTLALGMVGD RLWKRVGREP SGNPFNSIVQ
110 120 130 140 150
LERERGVPRN PFINAGAIAV TDVILSGHEP REALGEILRF MQFLAQDSGI
160 170 180 190 200
IIDETVAASE KRTGFRNTAL ANYMKSFGVI DNPVDYTLGV YFHHCAIAMN
210 220 230 240 250
CRQLARAGRF LAHNGVNPST GHSVVSAERA RRINAIMLTC GHYDGSGEFA
260 270 280 290 300
YRVGLPGKSG VGGSILAIAP GKASIAVWSP GLDAAGNSHL GRIALERLTQ

RMGWSVFGA
Length:309
Mass (Da):33,255
Last modified:April 29, 2008 - v1
Checksum:i8674227C6EA2F188
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001001 Genomic DNA. Translation: ACB25506.1.
RefSeqiWP_012320467.1. NC_010505.1.

Genome annotation databases

EnsemblBacteriaiACB25506; ACB25506; Mrad2831_3529.
GeneIDi6139582.
KEGGimrd:Mrad2831_3529.
PATRICi22575468. VBIMetRad70578_3609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001001 Genomic DNA. Translation: ACB25506.1.
RefSeqiWP_012320467.1. NC_010505.1.

3D structure databases

ProteinModelPortaliB1LUS0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426355.Mrad2831_3529.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB25506; ACB25506; Mrad2831_3529.
GeneIDi6139582.
KEGGimrd:Mrad2831_3529.
PATRICi22575468. VBIMetRad70578_3609.

Phylogenomic databases

eggNOGiENOG4105CSV. Bacteria.
COG2066. LUCA.
HOGENOMiHOG000216890.
KOiK01425.
OMAiANYMKSF.
OrthoDBiPOG091H02PU.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLSA_METRJ
AccessioniPrimary (citable) accession number: B1LUS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.