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B1LR29 (MUTH_ECOSM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutH
Alternative name(s):
Methyl-directed mismatch repair protein
Gene names
Name:mutH
Ordered Locus Names:EcSMS35_2979
OrganismEscherichia coli (strain SMS-3-5 / SECEC) [Complete proteome] [HAMAP]
Taxonomic identifier439855 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair By similarity. HAMAP-Rule MF_00759

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00759.

Sequence similarities

Belongs to the MutH family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA modification

Inferred from electronic annotation. Source: InterPro

DNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

endonuclease activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229DNA mismatch repair protein MutH HAMAP-Rule MF_00759
PRO_1000133467

Sequences

Sequence LengthMass (Da)Tools
B1LR29 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 7EC2BD945E963A9C

FASTA22925,527
        10         20         30         40         50         60 
MSQPRPLLSP PETEEQLLAQ AQQLSGYTLG ELAALAGLVT PENLKRDKGW IGVLLEIWLG 

        70         80         90        100        110        120 
ASAGSKPEQD FAALGVELKT IPVDSLGRPL ETTFVCVAPL TGNSGVTWET SHVRHKLKRV 

       130        140        150        160        170        180 
LWIPVEGERS IPLAQRRVGS PLLWSPNEEE DRQLREDWEE LMDMIVLGQV ERITARHGEY 

       190        200        210        220 
LQIRPKAANA KALTEAIGVR GERILTLPRG FYLKKNFTSA LLARHFLIQ 

« Hide

References

[1]"Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5."
Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C., Ravel J., Stepanauskas R.
J. Bacteriol. 190:6779-6794(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SMS-3-5 / SECEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000970 Genomic DNA. Translation: ACB16837.1.
RefSeqYP_001745000.1. NC_010498.1.

3D structure databases

ProteinModelPortalB1LR29.
SMRB1LR29. Positions 3-229.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439855.EcSMS35_2979.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB16837; ACB16837; EcSMS35_2979.
GeneID6145783.
KEGGecm:EcSMS35_2979.
PATRIC18434870. VBIEscCol6161_3131.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3066.
HOGENOMHOG000271839.
KOK03573.
OMALRPKGAN.
OrthoDBEOG6CGCC0.
ProtClustDBPRK05070.

Enzyme and pathway databases

BioCycECOL439855:GHHB-2975-MONOMER.

Family and domain databases

Gene3D3.40.600.10. 1 hit.
HAMAPMF_00759. MutH.
InterProIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamPF02976. MutH. 1 hit.
[Graphical view]
SMARTSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMSSF52980. SSF52980. 1 hit.
TIGRFAMsTIGR02248. mutH_TIGR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMUTH_ECOSM
AccessionPrimary (citable) accession number: B1LR29
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families