B1LR29 (MUTH_ECOSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein MutH

Alternative name(s):
Methyl-directed mismatch repair protein

Gene names

Name:	mutH
Ordered Locus Names:	EcSMS35_2979

Organism

Escherichia coli (strain SMS-3-5 / SECEC) [Complete proteome] [HAMAP]

Taxonomic identifier

439855 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair By similarity. HAMAP-Rule MF_00759
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00759.
Sequence similarities	Belongs to the MutH family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA modification Inferred from electronic annotation. Source: InterPro DNA repair Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	DNA mismatch repair protein MutH HAMAP-Rule MF_00759		PRO_1000133467

Sequences

	Sequence		Length	Mass (Da)
	B1LR29 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 7EC2BD945E963A9C	FASTA	229	25,527
	10 20 30 40 50 60 MSQPRPLLSP PETEEQLLAQ AQQLSGYTLG ELAALAGLVT PENLKRDKGW IGVLLEIWLG 70 80 90 100 110 120 ASAGSKPEQD FAALGVELKT IPVDSLGRPL ETTFVCVAPL TGNSGVTWET SHVRHKLKRV 130 140 150 160 170 180 LWIPVEGERS IPLAQRRVGS PLLWSPNEEE DRQLREDWEE LMDMIVLGQV ERITARHGEY 190 200 210 220 LQIRPKAANA KALTEAIGVR GERILTLPRG FYLKKNFTSA LLARHFLIQ

References

[1]

"Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5." Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C., Ravel J., Stepanauskas R. J. Bacteriol. 190:6779-6794(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SMS-3-5 / SECEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000970 Genomic DNA. Translation: ACB16837.1.
RefSeq	YP_001745000.1. NC_010498.1.
3D structure databases
ProteinModelPortal	B1LR29.
SMR	B1LR29. Positions 3-229.
ModBase	Search...
Protein-protein interaction databases
STRING	439855.EcSMS35_2979.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACB16837; ACB16837; EcSMS35_2979.
GeneID	6145783.
KEGG	ecm:EcSMS35_2979.
PATRIC	18434870. VBIEscCol6161_3131.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3066.
HOGENOM	HOG000271839.
KO	K03573.
OMA	LRPKGAN.
ProtClustDB	PRK05070.
Enzyme and pathway databases
BioCyc	ECOL439855:GHHB-2975-MONOMER.
Family and domain databases
Gene3D	3.40.600.10. 1 hit.
HAMAP	MF_00759. MutH.
InterPro	IPR004230. DNA_mismatch_repair_MutH. IPR011337. DNA_rep_MutH/RE_typeII. IPR011335. Restrct_endonuc-II-like. [Graphical view]
Pfam	PF02976. MutH. 1 hit. [Graphical view]
SMART	SM00927. MutH. 1 hit. [Graphical view]
SUPFAM	SSF52980. Restrict_endonuc_II-like_core. 1 hit.
TIGRFAMs	TIGR02248. mutH_TIGR. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MUTH_ECOSM

Accession

Primary (citable) accession number: B1LR29

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 29, 2008
Last modified:	May 29, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program