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B1LQ64 (B1LQ64_ECOSM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5'/3'-nucleotidase SurE HAMAP MF_00060
EC=3.1.3.5 HAMAP MF_00060
EC=3.1.3.6 HAMAP MF_00060
Alternative name(s):
Exopolyphosphatase HAMAP MF_00060
Nucleoside monophosphate phosphohydrolase HAMAP MF_00060
Gene names
Name:surE HAMAP MF_00060
Ordered Locus Names:EcSMS35_2869
OrganismEscherichia coli (strain SMS-3-5 / SECEC) [Complete proteome] [HAMAP] EMBL ACB17265.1
Taxonomic identifier439855 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs By similarity. HAMAP MF_00060

Catalytic activity

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate. HAMAP MF_00060

A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060

Cofactor

Binds 1 divalent metal cation per subunit By similarity. HAMAP MF_00060

Subcellular location

Cytoplasm By similarity HAMAP MF_00060.

Sequence similarities

Belongs to the surE nucleotidase family. HAMAP MF_00060

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding101Divalent metal cation By similarity HAMAP MF_00060
Metal binding111Divalent metal cation By similarity HAMAP MF_00060
Metal binding411Divalent metal cation By similarity HAMAP MF_00060
Metal binding941Divalent metal cation By similarity HAMAP MF_00060

Sequences

Sequence LengthMass (Da)Tools
B1LQ64 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 339DE9C3EE00FCE2

FASTA25527,145
        10         20         30         40         50         60 
MIMRILLSND DGVHAPGIQT LAKALREFAD VQVVAPDRNR SGASNSLTLE SSLRTFTFEN 

        70         80         90        100        110        120 
GDIAVQMGTP TDCVYLGVNA LMRPRPDIVV SGINAGPNLG DDVIYSGTVA AAMEGRHLGF 

       130        140        150        160        170        180 
PALAVSLDGH KHYDTAAAVT CSILRALCKE PLRTGRILNI NVPDLPLDQI KGIRVTRCGT 

       190        200        210        220        230        240 
RHPADQVIPQ QDPRGNTLYW IGPPGGKCDA GPGTDFAAVD EGYVSITPLH VDLTAHSAQD 

       250 
VVSDWLNSVG VGTQW

« Hide

References

[1]"Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5."
Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C., Ravel J., Stepanauskas R.
J. Bacteriol. 190:6779-6794(2008) [PubMed: 18708504] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000970 Genomic DNA. Translation: ACB17265.1.
RefSeqYP_001744893.1. NC_010498.1.

3D structure databases

ProteinModelPortalB1LQ64.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1LQ64.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000062300; EBESCP00000059942; EBESCG00000061347.
GeneID6146359.
GenomeReviewsGene locus EcSMS35_2869 in contig CP000970_GR.
KEGGecm:EcSMS35_2869.
PATRIC18434646. VBIEscCol6161_3022.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000011302.
HOGENOMHBG600532.
OMAKHTASAG.
ProtClustDBPRK00346.

Family and domain databases

HAMAPMF_00060. SurE.
[Tree]
InterProIPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
Gene3DG3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KOK03787.
PfamPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMSSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMsTIGR00087. SurE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1LQ64_ECOSM
AccessionPrimary (citable) accession number: B1LQ64
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info