B1LPR3 (PHNN_ECOSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose 1,5-bisphosphate phosphokinase PhnN
EC=2.7.4.23

Alternative name(s):
Ribose 1,5-bisphosphokinase

Gene names

Name:	phnN
Ordered Locus Names:	EcSMS35_4560

Organism

Escherichia coli (strain SMS-3-5 / SECEC) [Complete proteome] [HAMAP]

Taxonomic identifier

439855 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) By similarity. HAMAP-Rule MF_00836
Catalytic activity	ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00836
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3. HAMAP-Rule MF_00836
Sequence similarities	Belongs to the ribose 1,5-bisphosphokinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	5-phosphoribose 1-diphosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP organic phosphonate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ribose 1,5-bisphosphate phosphokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Ribose 1,5-bisphosphate phosphokinase PhnN HAMAP-Rule MF_00836		PRO_0000412784

Sequences

	Sequence		Length	Mass (Da)
	B1LPR3 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 4CD4D1C88B741F03	FASTA	185	20,664
	10 20 30 40 50 60 MTGKLIWLMG ASGSGKDSLL TELRQREQTQ LLVAHRYITR AASAGSENHI ALSEQEFFTR 70 80 90 100 110 120 AGQNLLALSW HANGLYYGVG VEIDLWLHAG FDVVVNGSRA HLPQARARYQ SALLPVCLQV 130 140 150 160 170 180 SPEILRQRLE NRGRENASEI NARLARAARY TPQDCLTLNN DGSLRQSVDK LLTLIHQKEK HHACL

References

[1]

"Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5." Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C., Ravel J., Stepanauskas R. J. Bacteriol. 190:6779-6794(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SMS-3-5 / SECEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000970 Genomic DNA. Translation: ACB16364.1.
RefSeq	YP_001746488.1. NC_010498.1.
3D structure databases
ProteinModelPortal	B1LPR3.
ModBase	Search...
Protein-protein interaction databases
STRING	439855.EcSMS35_4560.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACB16364; ACB16364; EcSMS35_4560.
GeneID	6147514.
KEGG	ecm:EcSMS35_4560.
PATRIC	18438036. VBIEscCol6161_4673.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3709.
HOGENOM	HOG000037637.
KO	K05774.
OMA	KVINVTA.
ProtClustDB	PRK10078.
Enzyme and pathway databases
BioCyc	ECOL439855:GHHB-906-MONOMER.
UniPathway	UPA00087; UER00175.
Family and domain databases
HAMAP	MF_00836. PhnN.
InterPro	IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR012699. PhnN. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR02322. phosphon_PhnN. 1 hit.
PROSITE	PS50052. GUANYLATE_KINASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHNN_ECOSM

Accession

Primary (citable) accession number: B1LPR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 21, 2011
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program