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B1LP88 (TRMN6_ECOSM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
tRNA1(Val) (adenine(37)-N6)-methyltransferase
EC=2.1.1.223
Alternative name(s):
tRNA m6A37 methyltransferase
Gene names
Name:yfiC
Ordered Locus Names:EcSMS35_2727
OrganismEscherichia coli (strain SMS-3-5 / SECEC) [Complete proteome] [HAMAP]
Taxonomic identifier439855 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates the adenine in position 37 of tRNA1(Val) (anticodon cmo5UAC) By similarity. HAMAP-Rule MF_01872

Catalytic activity

S-adenosyl-L-methionine + adenine37 in tRNA1(Val) = S-adenosyl-L-homocysteine + N(6)-methyladenine37 in tRNA1(Val). HAMAP-Rule MF_01872

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_01872.

Sequence similarities

Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

tRNA (adenine-N6-)-methyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245tRNA1(Val) (adenine(37)-N6)-methyltransferase HAMAP-Rule MF_01872
PRO_0000387362

Sequences

Sequence LengthMass (Da)Tools
B1LP88 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: CEB4F1E3A849B7E3

FASTA24527,270
        10         20         30         40         50         60 
MSQSTSVLRR NGFTFKQFFV AHDRCAMKVG TDGILLGAWA PVAGVKRCLD IGAGSGLLAL 

        70         80         90        100        110        120 
MLAQRTDDSV MIDAVELESE AAAQAQENIN QSPWAERINV HTADIQQWIT QQTVRFDLII 

       130        140        150        160        170        180 
SNPPYYQQGV ECSTPQREQA RYTTTLDHPS LLTCAAECIT EEGFFCVVLP EQIGNGFTEL 

       190        200        210        220        230        240 
ALSMGWHLRL RTDVAENEAR LPHRVLLAFS PQAGECFSDR LVIRGPDQNY SEAYTALTQA 


FYLFM

« Hide

References

[1]"Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5."
Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C., Ravel J., Stepanauskas R.
J. Bacteriol. 190:6779-6794(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SMS-3-5 / SECEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000970 Genomic DNA. Translation: ACB15596.1.
RefSeqYP_001744764.1. NC_010498.1.

3D structure databases

ProteinModelPortalB1LP88.
SMRB1LP88. Positions 44-165.
ModBaseSearch...

Protein-protein interaction databases

STRING439855.EcSMS35_2727.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB15596; ACB15596; EcSMS35_2727.
GeneID6145556.
KEGGecm:EcSMS35_2727.
PATRIC18434360. VBIEscCol6161_2889.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4123.
HOGENOMHOG000283147.
KOK15460.
OMAFKQFHIN.
ProtClustDBCLSK880437.

Enzyme and pathway databases

BioCycECOL439855:GHHB-127-MONOMER.

Family and domain databases

HAMAPMF_01872. tRNA_methyltr_YfiC.
InterProIPR002052. DNA_methylase_N6_adenine_CS.
IPR022882. tRNA_adenine-N6_MeTrfase.
[Graphical view]
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRMN6_ECOSM
AccessionPrimary (citable) accession number: B1LP88
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: April 29, 2008
Last modified: May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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