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B1LLG1 (SUCC_ECOSM) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta

EC=6.2.1.5
Alternative name(s):
Succinyl-CoA synthetase subunit beta
Short name=SCS-beta
Gene names
Name:sucC
Ordered Locus Names:EcSMS35_0740
OrganismEscherichia coli (strain SMS-3-5 / SECEC) [Complete proteome] [HAMAP]
Taxonomic identifier439855 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP-Rule MF_00558

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. HAMAP-Rule MF_00558

Subunit structure

Heterotetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the succinate/malate CoA ligase beta subunit family.

Contains 1 ATP-grasp domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP-Rule MF_00558
PRO_1000129188

Regions

Domain9 – 244236ATP-grasp
Nucleotide binding35 – 10874ATP By similarity

Sites

Metal binding1971Magnesium or manganese By similarity
Metal binding1991Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
B1LLG1 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 09C429EC97A823CF

FASTA38841,393
        10         20         30         40         50         60 
MNLHEYQAKQ LFARYGLPAP VGYACTTPRE AEEAASKIGA GPWVVKCQVH AGGRGKAGGV 

        70         80         90        100        110        120 
KVVNSKEDIR AFAENWLGKR LVTYQTDANG QPVNQILVEA ATDIAKELYL GAVVDRSSRR 

       130        140        150        160        170        180 
VVFMASTEGG VEIEKVAEET PHLIHKVALD PLTGPMPYQG RELAFKLGLE GKLVQQFTKI 

       190        200        210        220        230        240 
FMGLATIFLE RDLALIEINP LVITKQGDLI CLDGKLGADG NALFRQPDLR EMRDQSQEDP 

       250        260        270        280        290        300 
REAQAAQWEL NYVALDGNIG CMVNGAGLAM GTMDIVKLHG GEPANFLDVG GGATKERVTE 

       310        320        330        340        350        360 
AFKIILSDDK VKAVLVNIFG GIVRCDLIAD GIIGAVAEVG VNVPVVVRLE GNNAELGAKK 

       370        380 
LADSGLNIIA AKGLTDAAQQ VVAAVEGK 

« Hide

References

[1]"Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5."
Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C., Ravel J., Stepanauskas R.
J. Bacteriol. 190:6779-6794(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SMS-3-5 / SECEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000970 Genomic DNA. Translation: ACB19410.1.
RefSeqYP_001742828.1. NC_010498.1.

3D structure databases

ProteinModelPortalB1LLG1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439855.EcSMS35_0740.

Proteomic databases

PRIDEB1LLG1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB19410; ACB19410; EcSMS35_0740.
GeneID6145198.
KEGGecm:EcSMS35_0740.
PATRIC18430317. VBIEscCol6161_0902.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0045.
HOGENOMHOG000007059.
KOK01903.
OMAKVVFMAS.
OrthoDBEOG644ZT0.

Enzyme and pathway databases

BioCycECOL439855:GHHB-738-MONOMER.
UniPathwayUPA00223; UER00999.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.261. 1 hit.
HAMAPMF_00558. Succ_CoA_beta.
InterProIPR011761. ATP-grasp.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005811. CoA_ligase.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR005809. Succ_CoA_synthase_bsu.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PANTHERPTHR11815. PTHR11815. 1 hit.
PfamPF08442. ATP-grasp_2. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFPIRSF001554. SucCS_beta. 1 hit.
SUPFAMSSF52210. SSF52210. 1 hit.
TIGRFAMsTIGR01016. sucCoAbeta. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUCC_ECOSM
AccessionPrimary (citable) accession number: B1LLG1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways