B1LKV7 (MQO_ECOSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4

Alternative name(s):
MQO
Malate dehydrogenase [quinone]

Gene names

Name:	mqo
Ordered Locus Names:	EcSMS35_2359

Organism

Escherichia coli (strain SMS-3-5 / SECEC) [Complete proteome] [HAMAP]

Taxonomic identifier

439855 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 548	548	Probable malate:quinone oxidoreductase HAMAP MF_00212		PRO_1000191312

Sequences

	Sequence		Length	Mass (Da)
	B1LKV7 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 3278BBCC24F6AFFF	FASTA	548	60,232
	10 20 30 40 50 60 MKKVTAMLFS MAVGLNAVSM AAKAKASEEQ ETDVLLIGGG IMSATLGTYL RELEPEWSMT 70 80 90 100 110 120 MVERLEGVAQ ESSNGWNNAG TGHSALMELN YTPQNADGSI SIEKAVAINE AFQISRQFWA 130 140 150 160 170 180 HQVERGVLRT PRSFINTVPH MSFVWGEDNV NFLRARYAAL QQSSLFRGMR YSEDHAQIKE 190 200 210 220 230 240 WAPLVMEGRD PQQKVAATRT EIGTDVNYGE ITRQLIASLQ KKSNFSLQLS SEVRALKRND 250 260 270 280 290 300 DNTWTVTVAD LKNGTAQNIR AKFVFIGAGG AALKLLQESG IPEAKDYAGF PVGGQFLVSE 310 320 330 340 350 360 NPDVVNHHLA KVYGKASVGA PPMSVPHIDT RVLDGKRVVL FGPFATFSTK FLKNGSLWDL 370 380 390 400 410 420 MSSTTTSNVM PMMHVGLDNF DLVKYLVSQV MLSEEDRFEA LKEYYPQAKK EDWRLWQAGQ 430 440 450 460 470 480 RVQIIKRDAE KGGVLRLGTE VVSDQQGTIA ALLGASPGAS TAAPIMLNLL EKVFGDRVSS 490 500 510 520 530 540 PQWQATLKAT VPSYGRKLNG DVAATERELQ YTSEVLGLKY DKPQAADSTP KPQLKPQPVQ KEVADIAL

References

[1]

"Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5." Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C., Ravel J., Stepanauskas R. J. Bacteriol. 190:6779-6794(2008) [PubMed: 18708504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SMS-3-5 / SECEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000970 Genomic DNA. Translation: ACB20106.1.
RefSeq	YP_001744404.1. NC_010498.1.
3D structure databases
ProteinModelPortal	B1LKV7.
SMR	B1LKV7. Positions 29-69, 214-320.
ModBase	Search...
Protein-protein interaction databases
STRING	B1LKV7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000063098; EBESCP00000060740; EBESCG00000062145.
GeneID	6143924.
GenomeReviews	Gene locus EcSMS35_2359 in contig CP000970_GR.
KEGG	ecm:EcSMS35_2359.
PATRIC	18433622. VBIEscCol6161_2527.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000010864.
HOGENOM	HBG289663.
OMA	KKWVPLM.
ProtClustDB	PRK05257.
Enzyme and pathway databases
BioCyc	ECOL439855:ECSMS35_2359-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO_ECOSM

Accession

Primary (citable) accession number: B1LKV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program