Reviewed, UniProtKB/Swiss-Prot B1LK48 (SECB_ECOSM)

Names and origin

Protein names

Recommended name:
    Protein-export protein secB

Gene names

Name:	secB
Ordered Locus Names:	EcSMS35_3946

Organism

Escherichia coli (strain SMS-3-5 / SECEC) [Complete proteome] [HAMAP]

Taxonomic identifier

439855 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor secA By similarity. HAMAP MF_00821
Subunit structure	Homotetramer, a dimer of dimers. One homotetramer interacts with 1 secA dimer By similarity. HAMAP MF_00821
Subcellular location	Cytoplasm By similarity HAMAP MF_00821.
Sequence similarities	Belongs to the secB family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Cytoplasm
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: HAMAP protein tetramerization Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: HAMAP transmembrane transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 155	155	Protein-export protein secB HAMAP MF_00821		PRO_1000195319

Sequences

	Sequence		Length	Mass (Da)
	B1LK48-1 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 00514C5F393A643D	FASTA	155	17,277
	10 20 30 40 50 60 MSEQNNTEMT FQIQRIYTKD ISFEAPNAPH VFQKDWQPEV KLDLDTASSQ LADDVYEVVL 70 80 90 100 110 120 RVTVTASLGE ETAFLCEVQQ GGIFSIAGIE GTQMAHCLGA YCPNILFPYA RECITSMVSR 130 140 150 GTFPQLNLAP VNFDALFMNY LQQQAGEGTE EHQDA

References

[1]

"Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5." Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C., Ravel J., Stepanauskas R. J. Bacteriol. 190:6779-6794(2008) [PubMed: 18708504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000970 Genomic DNA. Translation: ACB17799.1.
RefSeq	YP_001745911.1.
3D structure databases
SMR	B1LK48. Positions 9-144.
ModBase	Search...
Genome annotation databases
GeneID	6147355.
GenomeReviews	Gene locus EcSMS35_3946 in contig CP000970_GR.
KEGG	ecm:EcSMS35_3946.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG294212.
OMA	GFPPLMI.
Family and domain databases
HAMAP	MF_00821. SecB. [Tree]
InterPro	IPR003708. SecB. [Graphical view]
Gene3D	G3DSA:3.10.420.10. SecB. 1 hit.
Pfam	PF02556. SecB. 1 hit. [Graphical view]
PRINTS	PR01594. SECBCHAPRONE.
TIGRFAMs	TIGR00809. secB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SECB_ECOSM

Accession

Primary (citable) accession number: B1LK48

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 29, 2008
Last modified:	February 9, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)