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B1LHH9 (B1LHH9_ECOSM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase HAMAP-Rule MF_00140
EC=6.1.1.2 HAMAP-Rule MF_00140
Alternative name(s):
Tryptophanyl-tRNA synthetase HAMAP-Rule MF_00140
Gene names
Name:trpS HAMAP-Rule MF_00140 EMBL ACB16982.1
Ordered Locus Names:EcSMS35_3660 EMBL ACB16982.1
OrganismEscherichia coli (strain SMS-3-5 / SECEC) [Complete proteome] [HAMAP] EMBL ACB16982.1
Taxonomic identifier439855 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). SAAS SAAS024109 HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. RuleBase RU003489 HAMAP-Rule MF_00140

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif12 – 209"HIGH" region By similarity HAMAP-Rule MF_00140
Motif195 – 1995"KMSKS" region By similarity HAMAP-Rule MF_00140

Sites

Binding site1981ATP By similarity HAMAP-Rule MF_00140

Sequences

Sequence LengthMass (Da)Tools
B1LHH9 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: DEB972FAFDAF3E28

FASTA33437,424
        10         20         30         40         50         60 
MTKPIVFSGA QPSGELTIGN YMGALRQWVN MQDDYHCIYC IVDQHAITVR QDAQKLRKAT 

        70         80         90        100        110        120 
LDTLALYLAC GIDPEKSTIF VQSHVPEHAQ LGWALNCYTY FGELSRMTQF KDKSARYAEN 

       130        140        150        160        170        180 
INAGLFDYPV LMAADILLYQ TNLVPVGEDQ KQHLELSRDI AQRFNALYGD IFKVPEPFIP 

       190        200        210        220        230        240 
KSGARVMSLL EPTKKMSKSD DNRNNVIGLL EDPKSVVKKI KRAVTDSDEP PVVRYDVQNK 

       250        260        270        280        290        300 
AGVSNLLDIL SAVTGQSIPE LEKQFEGKMY GHLKGEVADA VSGMLTELQE RYHRFRNDEA 

       310        320        330 
FLQQVMKDGA EKASAHASRT LKAVYEAIGF VAKP

« Hide

References

[1]"Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5."
Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C., Ravel J., Stepanauskas R.
J. Bacteriol. 190:6779-6794(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SMS-3-5 / SECEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000970 Genomic DNA. Translation: ACB16982.1.
RefSeqYP_001745627.1. NC_010498.1.

3D structure databases

ProteinModelPortalB1LHH9.
SMRB1LHH9. Positions 4-332.
ModBaseSearch...

Protein-protein interaction databases

STRING439855.EcSMS35_3660.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB16982; ACB16982; EcSMS35_3660.
GeneID6144938.
KEGGecm:EcSMS35_3660.
PATRIC18436251. VBIEscCol6161_3809.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059940.
KOK01867.
OMAHDCLYCV.
ProtClustDBPRK00927.

Enzyme and pathway databases

BioCycECOL439855:GHHB-1537-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1LHH9_ECOSM
AccessionPrimary (citable) accession number: B1LHH9
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info