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B1LDY4 (ASTA_ECOSM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Arginine N-succinyltransferase
Short name=AST
EC=2.3.1.109
Alternative name(s):
AOST
Gene names
Name:astA
Ordered Locus Names:EcSMS35_1444
OrganismEscherichia coli (strain SMS-3-5 / SECEC) [Complete proteome] [HAMAP]
Taxonomic identifier439855 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine By similarity. HAMAP-Rule MF_01171

Catalytic activity

Succinyl-CoA + L-arginine = CoA + N(2)-succinyl-L-arginine. HAMAP-Rule MF_01171

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 1/5. HAMAP-Rule MF_01171

Sequence similarities

Belongs to the arginine N-succinyltransferase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine catabolic process to glutamate

Inferred from electronic annotation. Source: HAMAP

arginine catabolic process to succinate

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionarginine N-succinyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Arginine N-succinyltransferase HAMAP-Rule MF_01171
PRO_1000137982

Sites

Active site2291Proton donor Potential
Binding site1251Succinyl-CoA; via amide nitrogen Potential

Sequences

Sequence LengthMass (Da)Tools
B1LDY4 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 89C7BB412A880BEF

FASTA34438,456
        10         20         30         40         50         60 
MMVIRPVERS DVSALMQLAS KTGGGLTSLP ANEATLSARI ERAIKTWQGE LPKSEQGYVF 

        70         80         90        100        110        120 
VLEDSETGTV AGICAIEVAV GLNDPWYNYR VGTLVHASKE LNVYNALPTL FLSNDHTGSS 

       130        140        150        160        170        180 
ELCTLFLDPD WRKEGNGYLL SKSRFMFMAA FRDKFNDKVV AEMRGVIDEH GYSPFWQSLG 

       190        200        210        220        230        240 
KRFFSMDFSR ADFLCGTGQK AFIAELMPKH PIYTHFLSQE AQDVIGQVHP QTAPARAVLE 

       250        260        270        280        290        300 
KEGFRYRNYI DIFDGGPTLE CDIDRVRAIR KSRLVEVAEG QPAQGDFPAC LVANENYHHF 

       310        320        330        340 
RVVLVRTDPA TERLILTAAQ LDALKCHAGD RVRLVRLCAE EKTA

« Hide

References

[1]"Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5."
Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C., Ravel J., Stepanauskas R.
J. Bacteriol. 190:6779-6794(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SMS-3-5 / SECEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000970 Genomic DNA. Translation: ACB17626.1.
RefSeqYP_001743502.1. NC_010498.1.

3D structure databases

ProteinModelPortalB1LDY4.
SMRB1LDY4. Positions 1-335.
ModBaseSearch...

Protein-protein interaction databases

STRING439855.EcSMS35_1444.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB17626; ACB17626; EcSMS35_1444.
GeneID6144195.
KEGGecm:EcSMS35_1444.
PATRIC18431757. VBIEscCol6161_1603.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3138.
HOGENOMHOG000258231.
KOK00673.
OMAAGPAIEC.
ProtClustDBPRK10456.

Enzyme and pathway databases

BioCycECOL439855:GHHB-2188-MONOMER.
UniPathwayUPA00185; UER00279.

Family and domain databases

Gene3D2.40.40.20. 1 hit.
3.40.630.30. 2 hits.
HAMAPMF_01171. AstA.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR007041. Arg_N-succinylTrfase_Ast/AOST.
IPR017650. Arginine_N-succinylTrfase_AstA.
IPR009010. Asp_de-COase-like_dom.
[Graphical view]
PfamPF04958. AstA. 1 hit.
[Graphical view]
SUPFAMSSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMsTIGR03243. arg_catab_AOST. 1 hit.
TIGR03244. arg_catab_AstA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASTA_ECOSM
AccessionPrimary (citable) accession number: B1LDY4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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