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B1LB32

- ASPD_THESQ

UniProt

B1LB32 - ASPD_THESQ

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Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Thermotoga sp. (strain RQ2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091NAD; via amide nitrogenUniRule annotation
Binding sitei164 – 1641NADUniRule annotation
Active sitei193 – 1931UniRule annotation

GO - Molecular functioni

  1. aspartate dehydrogenase activity Source: UniProtKB-EC
  2. NAD binding Source: UniProtKB-HAMAP
  3. NADP binding Source: UniProtKB-HAMAP
  4. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. NADP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciTSP126740:GH49-1222-MONOMER.
UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
Gene namesi
Name:nadXUniRule annotation
Ordered Locus Names:TRQ2_1186
OrganismiThermotoga sp. (strain RQ2)
Taxonomic identifieri126740 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000001687: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Probable L-aspartate dehydrogenasePRO_1000140090Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi126740.TRQ2_1186.

Structurei

3D structure databases

ProteinModelPortaliB1LB32.
SMRiB1LB32. Positions 1-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000206326.
KOiK06989.
OMAiECAGHSA.
OrthoDBiEOG6ND0JC.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01265. NadX.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR022487. Asp_DH_arc.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.
TIGRFAMsiTIGR03855. NAD_NadX. 1 hit.

Sequencei

Sequence statusi: Complete.

B1LB32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVLIIGMGN IGKKLVELGN FEKIYAYDRI SKDIPGVVRL GEFQVPSDVS
60 70 80 90 100
TVVECASPEA VKEYSLQILK SPVNYIIIST SAFADEVFRE RFFSELKNSP
110 120 130 140 150
ARVFFPSGAI GGLDVLSSIK DFVETVRIET IKPPKSLGLD LKGKTVVFEG
160 170 180 190 200
SVEEASKLFP RNINVASTIG LIVGFEKVKV TIVADPAMDH NIHIVRISSA
210 220 230 240
IGNYEFKIEN IPSPENPKTS MLTVYSILRA LRNLESKIVF G
Length:241
Mass (Da):26,499
Last modified:April 29, 2008 - v1
Checksum:iA7E5A04E3C7B3E82
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000969 Genomic DNA. Translation: ACB09530.1.
RefSeqiYP_001739213.1. NC_010483.1.

Genome annotation databases

EnsemblBacteriaiACB09530; ACB09530; TRQ2_1186.
GeneIDi6092621.
KEGGitrq:TRQ2_1186.
PATRICi23948974. VBITheSp108950_1207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000969 Genomic DNA. Translation: ACB09530.1 .
RefSeqi YP_001739213.1. NC_010483.1.

3D structure databases

ProteinModelPortali B1LB32.
SMRi B1LB32. Positions 1-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 126740.TRQ2_1186.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB09530 ; ACB09530 ; TRQ2_1186 .
GeneIDi 6092621.
KEGGi trq:TRQ2_1186.
PATRICi 23948974. VBITheSp108950_1207.

Phylogenomic databases

eggNOGi COG1712.
HOGENOMi HOG000206326.
KOi K06989.
OMAi ECAGHSA.
OrthoDBi EOG6ND0JC.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00456 .
BioCyci TSP126740:GH49-1222-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01265. NadX.
InterProi IPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR022487. Asp_DH_arc.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
TIGRFAMsi TIGR03855. NAD_NadX. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RQ2.

Entry informationi

Entry nameiASPD_THESQ
AccessioniPrimary (citable) accession number: B1LB32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3