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B1LAQ7

- FTHS_THESQ

UniProt

B1LAQ7 - FTHS_THESQ

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermotoga sp. (strain RQ2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi53 – 608ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTSP126740:GH49-1091-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:TRQ2_1058
    OrganismiThermotoga sp. (strain RQ2)
    Taxonomic identifieri126740 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000001687: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542Formate--tetrahydrofolate ligasePRO_1000146708Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi126740.TRQ2_1058.

    Structurei

    3D structure databases

    ProteinModelPortaliB1LAQ7.
    SMRiB1LAQ7. Positions 1-540.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1LAQ7-1 [UniParc]FASTAAdd to Basket

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    MKPIKEIADQ LGLKDDVLYP YGHYIAKIDH RFLKSLENRE DGKLILVTAV    50
    TPTPAGEGKT TTSIGLSMSL NRIGKKSIVT LREPSLGPTL GLKGGATGGG 100
    RSRVLPSDEI NLHFTGDMHA VASAHNLLAA VLDSHIKHGN ELKIDITRVF 150
    WKRTMDMNDR ALRSIVIGLG GSANGFPRED SFIITAASEV MAVLALSENM 200
    KDLKERLGKI IVALNTDRKI VRVSDLRIQG AMAVLLKDAI NPNLVQTTEG 250
    TPALIHCGPF ANIAHGTNSI IATKMAMKLS EYTVTEAGFG ADLGAEKFID 300
    FVSRVGGFYP NAAVLVATVR ALKYHGGADL KNIHEENLEA LKEGFKNLRV 350
    HLENLRKFNL PVVVALNRFI TDTEKEIAYV VKECEKLGVR VAVSEVFEKG 400
    SEGGVELAKA VTEAVKDVKP VYLYEMNDPV EKKIEILAKE IYRAGRVEFS 450
    DTAKNALKFI KKHGFDELPV IVAKTPKSIS HDPSLRGAPE GYTFVVSDLF 500
    VSAGAGFVVA LSGDINLMPG LPERPNALNM DVDDSGNIVG VS 542
    Length:542
    Mass (Da):58,727
    Last modified:April 29, 2008 - v1
    Checksum:iAB6E352402AEF6C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000969 Genomic DNA. Translation: ACB09405.1.
    RefSeqiWP_012310915.1. NC_010483.1.
    YP_001739088.1. NC_010483.1.

    Genome annotation databases

    EnsemblBacteriaiACB09405; ACB09405; TRQ2_1058.
    GeneIDi6092490.
    KEGGitrq:TRQ2_1058.
    PATRICi23948700. VBITheSp108950_1073.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000969 Genomic DNA. Translation: ACB09405.1 .
    RefSeqi WP_012310915.1. NC_010483.1.
    YP_001739088.1. NC_010483.1.

    3D structure databases

    ProteinModelPortali B1LAQ7.
    SMRi B1LAQ7. Positions 1-540.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 126740.TRQ2_1058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB09405 ; ACB09405 ; TRQ2_1058 .
    GeneIDi 6092490.
    KEGGi trq:TRQ2_1058.
    PATRICi 23948700. VBITheSp108950_1073.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci TSP126740:GH49-1091-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RQ2.

    Entry informationi

    Entry nameiFTHS_THESQ
    AccessioniPrimary (citable) accession number: B1LAQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3