B1L9U1 (GCST_THESQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	TRQ2_0737

Organism

Thermotoga sp. (strain RQ2) [Complete proteome] [HAMAP]

Taxonomic identifier

126740 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Aminomethyltransferase HAMAP MF_00259		PRO_1000114124

Sequences

	Sequence		Length	Mass (Da)
	B1L9U1 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: F7180C071E9DA1BD	FASTA	364	40,291
	10 20 30 40 50 60 MKRTPLFEKH VELGAKMVDF AGWEMPLYYT SIFEEVMAVR KSVGMFDVSH MGEFLVKGPE 70 80 90 100 110 120 AVSFIDFLIT NNFSSLPDGK ALYSVMCNEN GGIIDDLVVY KVSPDEALMV VNAANIEKDF 130 140 150 160 170 180 NWIKSHSKNF NVEVSNISDT TALIAFQGPR AQEALQELVE DSLEEIAYYS FKKSIVAGVE 190 200 210 220 230 240 AIVSRTGYTG EDGFELMIEA KNSPKVWDAL MNLLRKIDGR PAGLGARDVC RLEATYLLYG 250 260 270 280 290 300 QDMDENTNPF EVGLSWVVKL DKDFVGKEAL LKAKEKVERK LVALELSGKR IARKGYEVSK 310 320 330 340 350 360 NGERVGEITS GNFSPTLGKS IALALVSKSV KIGDQLGVVF PGGKLVEALV VKKPFYRGSV RREV

References

[1]

"Complete sequence of Thermotoga sp. RQ2." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D.B., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RQ2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000969 Genomic DNA. Translation: ACB09089.1.
RefSeq	YP_001738772.1. NC_010483.1.
3D structure databases
ProteinModelPortal	B1L9U1.
SMR	B1L9U1. Positions 1-362.
ModBase	Search...
Protein-protein interaction databases
STRING	B1L9U1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6092154.
GenomeReviews	Gene locus TRQ2_0737 in contig CP000969_GR.
KEGG	trq:TRQ2_0737.
PATRIC	23948024. VBITheSp108950_0749.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	VINASNK.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	TSP28240:TRQ2_0737-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_THESQ

Accession

Primary (citable) accession number: B1L9U1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program