Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B1L9T9

- GCSPA_THESQ

UniProt

B1L9T9 - GCSPA_THESQ

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Thermotoga sp. (strain RQ2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciTSP126740:GH49-753-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:TRQ2_0735
    OrganismiThermotoga sp. (strain RQ2)
    Taxonomic identifieri126740 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000001687: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000132489Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi126740.TRQ2_0735.

    Structurei

    3D structure databases

    ProteinModelPortaliB1L9T9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiRLVGQTE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1L9T9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYPYIPHTD EDVRAMLDFI GVSSIEELFS SIPVSARSSL NLPESRDEFG    50
    VFKRLKEISE MNTSLEDHAV FLGAGVYKRY VPMVVYDLAM KPDFLTAYTP 100
    YQAEVSQGTL QALFEYQTMV CELTGMEVAN ASMYDGATAL AEAALMSFRL 150
    TGKEKVVVAR SVHPEYRAVL RTYLEKRGFT VVEAGYDETG RVLLEEVDEE 200
    TAAIAVQYPN FFGVIEDLDY VRSRSGNALL IVVVEPVSLA LLEPPGSYGA 250
    DIVVGEGQSL GLPMWFGGYS LGIFATREKY VRQMPGRLIG QTVDQAGNTA 300
    YTMILQTREQ HIRRARATSN ICSNHAHAAL IAAVYMSVMG PDGLREVARR 350
    SYSAAHYLQE RLEEMGFKLR FSGEFFNEFV FNVPEDYPER WKWMMAKKIL 400
    GPLPLKGFYP ELGDTALACA TEVTSKEDIE KLLEAMK 437
    Length:437
    Mass (Da):48,889
    Last modified:April 29, 2008 - v1
    Checksum:i5379C5D00B18547D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000969 Genomic DNA. Translation: ACB09087.1.
    RefSeqiWP_012310712.1. NC_010483.1.
    YP_001738770.1. NC_010483.1.

    Genome annotation databases

    EnsemblBacteriaiACB09087; ACB09087; TRQ2_0735.
    GeneIDi6092152.
    KEGGitrq:TRQ2_0735.
    PATRICi23948020. VBITheSp108950_0747.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000969 Genomic DNA. Translation: ACB09087.1 .
    RefSeqi WP_012310712.1. NC_010483.1.
    YP_001738770.1. NC_010483.1.

    3D structure databases

    ProteinModelPortali B1L9T9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 126740.TRQ2_0735.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB09087 ; ACB09087 ; TRQ2_0735 .
    GeneIDi 6092152.
    KEGGi trq:TRQ2_0735.
    PATRICi 23948020. VBITheSp108950_0747.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi RLVGQTE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci TSP126740:GH49-753-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RQ2.

    Entry informationi

    Entry nameiGCSPA_THESQ
    AccessioniPrimary (citable) accession number: B1L9T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3