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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Thermotoga sp. (strain RQ2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciTSP126740:G1GBG-759-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:TRQ2_0735
OrganismiThermotoga sp. (strain RQ2)
Taxonomic identifieri126740 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000001687 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001324891 – 437Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST437

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB1L9T9
SMRiB1L9T9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B1L9T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYPYIPHTD EDVRAMLDFI GVSSIEELFS SIPVSARSSL NLPESRDEFG
60 70 80 90 100
VFKRLKEISE MNTSLEDHAV FLGAGVYKRY VPMVVYDLAM KPDFLTAYTP
110 120 130 140 150
YQAEVSQGTL QALFEYQTMV CELTGMEVAN ASMYDGATAL AEAALMSFRL
160 170 180 190 200
TGKEKVVVAR SVHPEYRAVL RTYLEKRGFT VVEAGYDETG RVLLEEVDEE
210 220 230 240 250
TAAIAVQYPN FFGVIEDLDY VRSRSGNALL IVVVEPVSLA LLEPPGSYGA
260 270 280 290 300
DIVVGEGQSL GLPMWFGGYS LGIFATREKY VRQMPGRLIG QTVDQAGNTA
310 320 330 340 350
YTMILQTREQ HIRRARATSN ICSNHAHAAL IAAVYMSVMG PDGLREVARR
360 370 380 390 400
SYSAAHYLQE RLEEMGFKLR FSGEFFNEFV FNVPEDYPER WKWMMAKKIL
410 420 430
GPLPLKGFYP ELGDTALACA TEVTSKEDIE KLLEAMK
Length:437
Mass (Da):48,889
Last modified:April 29, 2008 - v1
Checksum:i5379C5D00B18547D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000969 Genomic DNA Translation: ACB09087.1
RefSeqiWP_012310712.1, NC_010483.1

Genome annotation databases

EnsemblBacteriaiACB09087; ACB09087; TRQ2_0735
KEGGitrq:TRQ2_0735

Similar proteinsi

Entry informationi

Entry nameiGCSPA_THESQ
AccessioniPrimary (citable) accession number: B1L9T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health