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Protein

Shikimate dehydrogenase

Gene

aroE

Organism
Thermotoga sp. (strain RQ2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Shikimate + NADP+ = 3-dehydroshikimate + NADPH.

Pathwayi: chorismate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (aroE)
  5. Shikimate kinase., 3-dehydroquinate synthase (TRQ2_0587)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Proton acceptorSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi115 – 119NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00053; UER00087.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate dehydrogenase (EC:1.1.1.25)
Gene namesi
Name:aroE
Ordered Locus Names:TRQ2_0589
OrganismiThermotoga sp. (strain RQ2)
Taxonomic identifieri126740 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000001687 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001001491 – 253Shikimate dehydrogenaseAdd BLAST253

Structurei

3D structure databases

ProteinModelPortaliB1L9E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000237875.
KOiK00014.
OMAiQPYGNIQ.
OrthoDBiPOG091H02DY.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_DH_fam.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamiPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

B1L9E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFCIIGYPV SHSISPRLYN EYFKRAGMNH SYGMEEIPPE SFDTEIRRIL
60 70 80 90 100
EEYDGFNATI PHKERVMRYV EPSEDAQRIK AVNCVFRGKG YNTDWVGVVK
110 120 130 140 150
SLEGVEVKEP VVVVGAGGAA RAVIYALLQM GVKDIWVVNR TIERAKALDF
160 170 180 190 200
PVKIFSLDQL DEVVKKAKSL FNTTSVGMKG EKLTVSEASL KGLYLVYDVV
210 220 230 240 250
YFETPLVSDA KRLGVEHVVK GNLMFYYQAM ENLKIWGIYD ERSFKEVFEE

VLR
Length:253
Mass (Da):28,874
Last modified:April 29, 2008 - v1
Checksum:iA56A15CAD162A3D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000969 Genomic DNA. Translation: ACB08942.1.
RefSeqiWP_011943195.1. NC_010483.1.

Genome annotation databases

EnsemblBacteriaiACB08942; ACB08942; TRQ2_0589.
KEGGitrq:TRQ2_0589.
PATRICi23947722. VBITheSp108950_0599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000969 Genomic DNA. Translation: ACB08942.1.
RefSeqiWP_011943195.1. NC_010483.1.

3D structure databases

ProteinModelPortaliB1L9E4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB08942; ACB08942; TRQ2_0589.
KEGGitrq:TRQ2_0589.
PATRICi23947722. VBITheSp108950_0599.

Phylogenomic databases

HOGENOMiHOG000237875.
KOiK00014.
OMAiQPYGNIQ.
OrthoDBiPOG091H02DY.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00087.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_DH_fam.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamiPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAROE_THESQ
AccessioniPrimary (citable) accession number: B1L9E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.