B1L9E4 (AROE_THESQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	TRQ2_0589

Organism

Thermotoga sp. (strain RQ2) [Complete proteome] [HAMAP]

Taxonomic identifier

126740 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000100149
Regions
	Nucleotide binding	115 – 119	5	NADP By similarity
Sites
	Active site	63	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	B1L9E4 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: A56A15CAD162A3D2	FASTA	253	28,874
	10 20 30 40 50 60 MKFCIIGYPV SHSISPRLYN EYFKRAGMNH SYGMEEIPPE SFDTEIRRIL EEYDGFNATI 70 80 90 100 110 120 PHKERVMRYV EPSEDAQRIK AVNCVFRGKG YNTDWVGVVK SLEGVEVKEP VVVVGAGGAA 130 140 150 160 170 180 RAVIYALLQM GVKDIWVVNR TIERAKALDF PVKIFSLDQL DEVVKKAKSL FNTTSVGMKG 190 200 210 220 230 240 EKLTVSEASL KGLYLVYDVV YFETPLVSDA KRLGVEHVVK GNLMFYYQAM ENLKIWGIYD 250 ERSFKEVFEE VLR

References

[1]

"Complete sequence of Thermotoga sp. RQ2." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D.B., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RQ2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000969 Genomic DNA. Translation: ACB08942.1.
RefSeq	YP_001738625.1. NC_010483.1.
3D structure databases
ProteinModelPortal	B1L9E4.
ModBase	Search...
Protein-protein interaction databases
STRING	B1L9E4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6092005.
GenomeReviews	Gene locus TRQ2_0589 in contig CP000969_GR.
KEGG	trq:TRQ2_0589.
PATRIC	23947722. VBITheSp108950_0599.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	LHLKTHG.
ProtClustDB	CLSK875100.
Enzyme and pathway databases
BioCyc	TSP28240:TRQ2_0589-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROE_THESQ

Accession

Primary (citable) accession number: B1L9E4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program