B1L7A5 (IF5A_KORCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor 5A

Alternative name(s):
Hypusine-containing protein
eIF-5A

Gene names

Name:	eIF5A
Ordered Locus Names:	Kcr_1589

Organism

Korarchaeum cryptofilum (strain OPF8) [Reference proteome] [HAMAP]

Taxonomic identifier

374847 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Korarchaeota › Candidatus Korarchaeum › Candidatus Korarchaeum cryptofilum

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Functions by promoting the formation of the first peptide bond By similarity. HAMAP-Rule MF_00085
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the eIF-5A family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
PTM	Hypusine
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-lysine modification to hypusine Inferred from electronic annotation. Source: InterPro positive regulation of translational elongation Inferred from electronic annotation. Source: InterPro positive regulation of translational termination Inferred from electronic annotation. Source: InterPro translational frameshifting Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ribosome binding Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 134	134	Translation initiation factor 5A HAMAP-Rule MF_00085		PRO_1000093008
Amino acid modifications
	Modified residue	36	1	Hypusine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1L7A5 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 8B3147BFBD2B2AAD	FASTA	134	14,821
	10 20 30 40 50 60 MSVTRGSAGD LRKGSYVILD DEPCEVLEVS KSKPGKHGSA KVRVEARGIF DGARRSKIFP 70 80 90 100 110 120 ADALVEIPIV DKKTAQVINV YGNVVQLMDL ETYETFELPL PEDPELASRL KSGIEVEYWE 130 SMGKRKIVRT RGGV

References

[1]

"A korarchaeal genome reveals new insights into the evolution of the Archaea." Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L., Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A., Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G., Richardson P., Keller M., Stetter K.O. Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OPF8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000968 Genomic DNA. Translation: ACB08334.1.
RefSeq	YP_001738017.1. NC_010482.1.
3D structure databases
ProteinModelPortal	B1L7A5.
ModBase	Search...
Protein-protein interaction databases
STRING	374847.Kcr_1589.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACB08334; ACB08334; Kcr_1589.
GeneID	6094865.
KEGG	kcr:Kcr_1589.
Phylogenomic databases
eggNOG	COG0231.
HOGENOM	HOG000106269.
KO	K03263.
OMA	EPCKIVE.
Enzyme and pathway databases
BioCyc	KCRY374847:GH12-1576-MONOMER.
Family and domain databases
Gene3D	2.30.30.30. 1 hit. 2.40.50.140. 1 hit.
HAMAP	MF_00085. eIF-5A.
InterPro	IPR012340. NA-bd_OB-fold. IPR014722. Rib_L2_dom2. IPR019769. Trans_elong_IF5A_hypusine_site. IPR001884. Transl_elong_IF5A. IPR022847. Transl_elong_IF5A_arc. IPR020189. Transl_elong_IF5A_C. IPR013185. Transl_elong_KOW-like. IPR008991. Translation_prot_SH3-like. [Graphical view]
PANTHER	PTHR11673. PTHR11673. 1 hit. PTHR11673:SF1. PTHR11673:SF1. 1 hit.
Pfam	PF08207. EFP_N. 1 hit. PF01287. eIF-5a. 1 hit. [Graphical view]
PIRSF	PIRSF003025. eIF5A. 1 hit.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF50104. Transl_SH3_like. 1 hit.
TIGRFAMs	TIGR00037. eIF_5A. 1 hit.
PROSITE	PS00302. IF5A_HYPUSINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF5A_KORCO

Accession

Primary (citable) accession number: B1L7A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program