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Protein

Translation initiation factor 5A

Gene

eIF5A

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Functions by promoting the formation of the first peptide bond.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 5AUniRule annotation
Alternative name(s):
Hypusine-containing proteinUniRule annotation
eIF-5AUniRule annotation
Gene namesi
Name:eIF5A
Ordered Locus Names:Kcr_1589
OrganismiKorarchaeum cryptofilum (strain OPF8)
Taxonomic identifieri374847 [NCBI]
Taxonomic lineageiArchaeaCandidatus KorarchaeotaCandidatus Korarchaeum
Proteomesi
  • UP000001686 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000930081 – 134Translation initiation factor 5AAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36HypusineUniRule annotation1

Keywords - PTMi

Hypusine

Interactioni

Protein-protein interaction databases

STRINGi374847.Kcr_1589.

Structurei

3D structure databases

ProteinModelPortaliB1L7A5.
SMRiB1L7A5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04277. Archaea.
COG0231. LUCA.
HOGENOMiHOG000106269.
InParanoidiB1L7A5.
KOiK03263.
OMAiQIMDMET.
OrthoDBiPOG093Z0HA5.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_00085. eIF_5A. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR022847. Transl_elong_IF5A_arc.
IPR020189. Transl_elong_IF5A_C.
IPR013185. Transl_elong_KOW-like.
IPR008991. Translation_prot_SH3-like.
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiView protein in Pfam
PF08207. EFP_N. 1 hit.
PF01287. eIF-5a. 1 hit.
PIRSFiPIRSF003025. eIF5A. 1 hit.
SMARTiView protein in SMART
SM01376. eIF-5a. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiView protein in PROSITE
PS00302. IF5A_HYPUSINE. 1 hit.

Sequencei

Sequence statusi: Complete.

B1L7A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTRGSAGD LRKGSYVILD DEPCEVLEVS KSKPGKHGSA KVRVEARGIF
60 70 80 90 100
DGARRSKIFP ADALVEIPIV DKKTAQVINV YGNVVQLMDL ETYETFELPL
110 120 130
PEDPELASRL KSGIEVEYWE SMGKRKIVRT RGGV
Length:134
Mass (Da):14,821
Last modified:April 29, 2008 - v1
Checksum:i8B3147BFBD2B2AAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000968 Genomic DNA. Translation: ACB08334.1.
RefSeqiWP_012310231.1. NC_010482.1.

Genome annotation databases

EnsemblBacteriaiACB08334; ACB08334; Kcr_1589.
GeneIDi6094865.
KEGGikcr:Kcr_1589.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIF5A_KORCO
AccessioniPrimary (citable) accession number: B1L7A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: June 7, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families