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B1L7A5

- IF5A_KORCO

UniProt

B1L7A5 - IF5A_KORCO

Protein

Translation initiation factor 5A

Gene

eIF5A

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Functions by promoting the formation of the first peptide bond.UniRule annotation

    GO - Molecular functioni

    1. ribosome binding Source: InterPro
    2. translation elongation factor activity Source: InterPro
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidyl-lysine modification to peptidyl-hypusine Source: InterPro
    2. positive regulation of translational elongation Source: InterPro
    3. positive regulation of translational termination Source: InterPro
    4. translational frameshifting Source: InterPro

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciKCRY374847:GH12-1630-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor 5AUniRule annotation
    Alternative name(s):
    Hypusine-containing proteinUniRule annotation
    eIF-5AUniRule annotation
    Gene namesi
    Name:eIF5A
    Ordered Locus Names:Kcr_1589
    OrganismiKorarchaeum cryptofilum (strain OPF8)
    Taxonomic identifieri374847 [NCBI]
    Taxonomic lineageiArchaeaKorarchaeotaCandidatus Korarchaeum
    ProteomesiUP000001686: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 134134Translation initiation factor 5APRO_1000093008Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei36 – 361HypusineUniRule annotation

    Keywords - PTMi

    Hypusine

    Interactioni

    Protein-protein interaction databases

    STRINGi374847.Kcr_1589.

    Structurei

    3D structure databases

    ProteinModelPortaliB1L7A5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eIF-5A family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0231.
    HOGENOMiHOG000106269.
    KOiK03263.
    OMAiAMGKMKI.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00085. eIF_5A.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR014722. Rib_L2_dom2.
    IPR019769. Trans_elong_IF5A_hypusine_site.
    IPR001884. Transl_elong_IF5A.
    IPR022847. Transl_elong_IF5A_arc.
    IPR020189. Transl_elong_IF5A_C.
    IPR013185. Transl_elong_KOW-like.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR11673. PTHR11673. 1 hit.
    PfamiPF08207. EFP_N. 1 hit.
    PF01287. eIF-5a. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003025. eIF5A. 1 hit.
    SUPFAMiSSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
    PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1L7A5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVTRGSAGD LRKGSYVILD DEPCEVLEVS KSKPGKHGSA KVRVEARGIF    50
    DGARRSKIFP ADALVEIPIV DKKTAQVINV YGNVVQLMDL ETYETFELPL 100
    PEDPELASRL KSGIEVEYWE SMGKRKIVRT RGGV 134
    Length:134
    Mass (Da):14,821
    Last modified:April 29, 2008 - v1
    Checksum:i8B3147BFBD2B2AAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000968 Genomic DNA. Translation: ACB08334.1.
    RefSeqiYP_001738017.1. NC_010482.1.

    Genome annotation databases

    EnsemblBacteriaiACB08334; ACB08334; Kcr_1589.
    GeneIDi6094865.
    KEGGikcr:Kcr_1589.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000968 Genomic DNA. Translation: ACB08334.1 .
    RefSeqi YP_001738017.1. NC_010482.1.

    3D structure databases

    ProteinModelPortali B1L7A5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374847.Kcr_1589.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB08334 ; ACB08334 ; Kcr_1589 .
    GeneIDi 6094865.
    KEGGi kcr:Kcr_1589.

    Phylogenomic databases

    eggNOGi COG0231.
    HOGENOMi HOG000106269.
    KOi K03263.
    OMAi AMGKMKI.

    Enzyme and pathway databases

    BioCyci KCRY374847:GH12-1630-MONOMER.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00085. eIF_5A.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR014722. Rib_L2_dom2.
    IPR019769. Trans_elong_IF5A_hypusine_site.
    IPR001884. Transl_elong_IF5A.
    IPR022847. Transl_elong_IF5A_arc.
    IPR020189. Transl_elong_IF5A_C.
    IPR013185. Transl_elong_KOW-like.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR11673. PTHR11673. 1 hit.
    Pfami PF08207. EFP_N. 1 hit.
    PF01287. eIF-5a. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003025. eIF5A. 1 hit.
    SUPFAMi SSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00037. eIF_5A. 1 hit.
    PROSITEi PS00302. IF5A_HYPUSINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OPF8.

    Entry informationi

    Entry nameiIF5A_KORCO
    AccessioniPrimary (citable) accession number: B1L7A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3