Reviewed, UniProtKB/Swiss-Prot B1L765 (GYAR_KORCO)

Names and origin

Protein names

Recommended name:
    Glyoxylate reductase
    EC=1.1.1.26

Gene names

Name:	gyaR
Ordered Locus Names:	Kcr_1548

Organism

Korarchaeum cryptofilum (strain OPF8) [Complete proteome] [HAMAP]

Taxonomic identifier

374847 [NCBI]

Taxonomic lineage

Archaea › Korarchaeota › Candidatus Korarchaeum

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Glycolate + NAD+ = glyoxylate + NADH. HAMAP MF_00776
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro glyoxylate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Glyoxylate reductase HAMAP MF_00776		PRO_0000348415
Regions
	Nucleotide binding	155 – 158	4	NADP By similarity
	Nucleotide binding	236 – 238	3	NADP By similarity
	Nucleotide binding	286 – 288	3	NADP By similarity
Sites
	Active site	238	1	By similarity
	Active site	267	1	By similarity
	Active site	286	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1L765-1 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 4A4A0FCA2D144207	FASTA	332	37,477
	10 20 30 40 50 60 MKPRVFVTRE IPERGLSKIE EHFELDLWKD EAPPSKKVII ERVKDCDALV SLLTDPIDAE 70 80 90 100 110 120 VFEAAPKLRI VAQYAVGYDN IDVKEATKRG IYVTNTPGVL TETTADFAFA LLMAAARRVV 130 140 150 160 170 180 EADRYVREGK WKVAWHPMMM LGYDVYGRTL GIVGMGRIGA AVARRAKGFG MRILYYDSIR 190 200 210 220 230 240 REDFEKELGV EYVPLEKLLE ESDFVSLHVP LTEETYHMIG EEQLRRMKRT AILVNTSRGK 250 260 270 280 290 300 VVDQKALYKA LKEGWIAGAG LDVFEQEPIP PDDPLLKLEN VVLAPHAASA SHETRSRMAE 310 320 330 MVAENLIAFK RGEIPPNLVN QEVVKVRPPG FQ

References

[1]

"A korarchaeal genome reveals new insights into the evolution of the Archaea." Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L., Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A., Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G., Richardson P., Keller M., Stetter K.O. Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008) [PubMed: 18535141] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000968 Genomic DNA. Translation: ACB08294.1.
RefSeq	YP_001737977.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6094825.
GenomeReviews	Gene locus Kcr_1548 in contig CP000968_GR.
KEGG	kcr:Kcr_1548.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	B1L765. TEDWGET.
Family and domain databases
HAMAP	MF_00776. [Tree]
InterPro	IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GYAR_KORCO

Accession

Primary (citable) accession number: B1L765

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	April 29, 2008
Last modified:	June 16, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)