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B1L6S7

- PSB1_KORCO

UniProt

B1L6S7 - PSB1_KORCO

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Protein

Proteasome subunit beta 1

Gene

psmB1

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei6 – 61NucleophileUniRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. proteasomal protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciKCRY374847:GH12-1438-MONOMER.

Protein family/group databases

MEROPSiT01.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta 1UniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome beta subunit 1UniRule annotation
Proteasome core protein PsmB 1UniRule annotation
Gene namesi
Name:psmB1UniRule annotation
Ordered Locus Names:Kcr_1410
OrganismiKorarchaeum cryptofilum (strain OPF8)
Taxonomic identifieri374847 [NCBI]
Taxonomic lineageiArchaeaKorarchaeotaCandidatus Korarchaeum
ProteomesiUP000001686: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. proteasome core complex, beta-subunit complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 55Removed in mature form; by autocatalysisUniRule annotationPRO_0000397322
Chaini6 – 206201Proteasome subunit beta 1PRO_0000397323Add
BLAST

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Protein-protein interaction databases

STRINGi374847.Kcr_1410.

Structurei

3D structure databases

ProteinModelPortaliB1L6S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000091083.
InParanoidiB1L6S7.
KOiK03433.
OMAiMVDWLGT.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02113_A. Proteasome_B_A.
InterProiIPR029055. Ntn_hydrolases_N.
IPR019983. Pept_T1A_Psome_bsu_arc.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1L6S7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLMKGTTTVG VKFKNGVIVA SDKRATSGTF VASKSAVKTL KITDYAVATI
60 70 80 90 100
SGLVADGQYL VNNVRTIADL YSLDTERPLS VRGIARILAF LLRRYRPYFL
110 120 130 140 150
LAQLIVGGVD REGAHLFNVD PFGTLTEEDY LATGSGSPVA ISVIESGYSP
160 170 180 190 200
DMDRESALRL VISSMTAALS RDAATGDGID VVVIDDRGVN FLSREEISDL

VREVLR
Length:206
Mass (Da):22,209
Last modified:April 29, 2008 - v1
Checksum:iE645564AE8C177A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000968 Genomic DNA. Translation: ACB08156.1.
RefSeqiYP_001737839.1. NC_010482.1.

Genome annotation databases

EnsemblBacteriaiACB08156; ACB08156; Kcr_1410.
GeneIDi6094687.
KEGGikcr:Kcr_1410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000968 Genomic DNA. Translation: ACB08156.1 .
RefSeqi YP_001737839.1. NC_010482.1.

3D structure databases

ProteinModelPortali B1L6S7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 374847.Kcr_1410.

Protein family/group databases

MEROPSi T01.002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB08156 ; ACB08156 ; Kcr_1410 .
GeneIDi 6094687.
KEGGi kcr:Kcr_1410.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000091083.
InParanoidi B1L6S7.
KOi K03433.
OMAi MVDWLGT.

Enzyme and pathway databases

BioCyci KCRY374847:GH12-1438-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_02113_A. Proteasome_B_A.
InterProi IPR029055. Ntn_hydrolases_N.
IPR019983. Pept_T1A_Psome_bsu_arc.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OPF8.

Entry informationi

Entry nameiPSB1_KORCO
AccessioniPrimary (citable) accession number: B1L6S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3