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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei163GTPUniRule annotation1
Binding sitei167GTPUniRule annotation1
Binding sitei210GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 49GTPUniRule annotation5
Nucleotide bindingi132 – 134GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, SeptationUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:Kcr_1343Imported
OrganismiKorarchaeum cryptofilum (strain OPF8)Imported
Taxonomic identifieri374847 [NCBI]
Taxonomic lineageiArchaeaCandidatus KorarchaeotaCandidatus Korarchaeum
Proteomesi
  • UP000001686 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi374847.Kcr_1343.

Structurei

3D structure databases

ProteinModelPortaliB1L6L0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 228TubulinInterPro annotationAdd BLAST192
Domaini230 – 347Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
HOGENOMiHOG000049094.
InParanoidiB1L6L0.
KOiK03531.
OMAiIWGTSVD.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1L6L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRTATRRVD EGVREIPQKV SPEDSSLKEF LEKVKARIVI MGVGGGGSNT
60 70 80 90 100
ITRLNAIGID SVETVAVNTD AQHLLITTAD RKLLIGKELC GGNGSGGDPH
110 120 130 140 150
IGEEAARESA DEIEEFLSGS DLLFIMAGLG GGTGTGASPV IAEIGKRVGA
160 170 180 190 200
AVVSVVTLPF TAEGAKKREI AMKGLAKLAS VSDTIVVVNN DKILEIAKEL
210 220 230 240 250
PLYQAFFISD EIVARAVKGV VELVVKPGLV NVDLADLRNV IESGGPAVLT
260 270 280 290 300
FGESDGENRA MEAVDDALGN PLLDADISGG KAAIINITSG PDFSLEEMQQ
310 320 330 340 350
IVETIVSSLD PNANVIWGAR IDESLKGSVQ VLLVVTGVAS PTVEAALQGE
360 370 380 390
LREPFVERAT KPKVEKAAKA LPRVTERKTI PIAREVRERS DLGIDEL
Length:397
Mass (Da):41,769
Last modified:April 29, 2008 - v1
Checksum:i1560F2E53101FBE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000968 Genomic DNA. Translation: ACB08089.1.

Genome annotation databases

EnsemblBacteriaiACB08089; ACB08089; Kcr_1343.
KEGGikcr:Kcr_1343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000968 Genomic DNA. Translation: ACB08089.1.

3D structure databases

ProteinModelPortaliB1L6L0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi374847.Kcr_1343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB08089; ACB08089; Kcr_1343.
KEGGikcr:Kcr_1343.

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
HOGENOMiHOG000049094.
InParanoidiB1L6L0.
KOiK03531.
OMAiIWGTSVD.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB1L6L0_KORCO
AccessioniPrimary (citable) accession number: B1L6L0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.