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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciCKOR374847:G1GBF-1216-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyaseUniRule annotation
Including the following 2 domains:
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Name:oggUniRule annotation
Ordered Locus Names:Kcr_1173
OrganismiKorarchaeum cryptofilum (strain OPF8)
Taxonomic identifieri374847 [NCBI]
Taxonomic lineageiArchaeaCandidatus KorarchaeotaCandidatus Korarchaeum
Proteomesi
  • UP000001686 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001007321 – 209Probable N-glycosylase/DNA lyaseAdd BLAST209

Interactioni

Protein-protein interaction databases

STRINGi374847.Kcr_1173

Structurei

3D structure databases

ProteinModelPortaliB1L640
SMRiB1L640
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04357 Archaea
COG1059 LUCA
HOGENOMiHOG000224507
InParanoidiB1L640
KOiK03653
OMAiGYKEASH
OrthoDBiPOG093Z0AOL

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
Gene3Di1.10.1670.10, 2 hits
HAMAPiMF_00241 Ogg, 1 hit
InterProiView protein in InterPro
IPR012092 DNA_glyclase/DNA_lyase_thermo
IPR011257 DNA_glycosylase
IPR003265 HhH-GPD_domain
IPR023170 HTH_base_excis_C
PIRSFiPIRSF005954 Thrmst_ogg, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit

Sequencei

Sequence statusi: Complete.

B1L640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVDDLVNDV MRLKGSRVRE IIERRMREFE RERSDEELFK ELVFCLLTAN
60 70 80 90 100
FSAEGGLRIL ESLGDGIFTL SEEELAAKLA ELGHRYPRKR AEFIVEARKL
110 120 130 140 150
IPILRDIISS FRDERLLREW LVKNVKGLGY KEASHFLRNI GFKNVSIIDY
160 170 180 190 200
HILDLLMKYG ILEEKPKSLS RARYLMIESI LEEISRRTGI NLGELDLYLW

YIETGKVLK
Length:209
Mass (Da):24,480
Last modified:April 29, 2008 - v1
Checksum:iD81590C93751EFE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000968 Genomic DNA Translation: ACB07919.1
RefSeqiWP_012309816.1, NC_010482.1

Genome annotation databases

EnsemblBacteriaiACB07919; ACB07919; Kcr_1173
GeneIDi6094450
KEGGikcr:Kcr_1173

Similar proteinsi

Entry informationi

Entry nameiOGG1_KORCO
AccessioniPrimary (citable) accession number: B1L640
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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