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B1L640

- OGG1_KORCO

UniProt

B1L640 - OGG1_KORCO

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Protein
Probable N-glycosylase/DNA lyase
Gene
ogg, Kcr_1173
Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311 By similarity

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciKCRY374847:GH12-1178-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:Kcr_1173
OrganismiKorarchaeum cryptofilum (strain OPF8)
Taxonomic identifieri374847 [NCBI]
Taxonomic lineageiArchaeaKorarchaeotaCandidatus Korarchaeum
ProteomesiUP000001686: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Probable N-glycosylase/DNA lyaseUniRule annotation
PRO_1000100732Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi374847.Kcr_1173.

Structurei

3D structure databases

ProteinModelPortaliB1L640.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
KOiK03653.
OMAiLDLYLWY.

Family and domain databases

HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

B1L640-1 [UniParc]FASTAAdd to Basket

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MGVDDLVNDV MRLKGSRVRE IIERRMREFE RERSDEELFK ELVFCLLTAN    50
FSAEGGLRIL ESLGDGIFTL SEEELAAKLA ELGHRYPRKR AEFIVEARKL 100
IPILRDIISS FRDERLLREW LVKNVKGLGY KEASHFLRNI GFKNVSIIDY 150
HILDLLMKYG ILEEKPKSLS RARYLMIESI LEEISRRTGI NLGELDLYLW 200
YIETGKVLK 209
Length:209
Mass (Da):24,480
Last modified:April 29, 2008 - v1
Checksum:iD81590C93751EFE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000968 Genomic DNA. Translation: ACB07919.1.
RefSeqiYP_001737602.1. NC_010482.1.

Genome annotation databases

EnsemblBacteriaiACB07919; ACB07919; Kcr_1173.
GeneIDi6094450.
KEGGikcr:Kcr_1173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000968 Genomic DNA. Translation: ACB07919.1 .
RefSeqi YP_001737602.1. NC_010482.1.

3D structure databases

ProteinModelPortali B1L640.
ModBasei Search...

Protein-protein interaction databases

STRINGi 374847.Kcr_1173.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB07919 ; ACB07919 ; Kcr_1173 .
GeneIDi 6094450.
KEGGi kcr:Kcr_1173.

Phylogenomic databases

eggNOGi COG1059.
HOGENOMi HOG000224507.
KOi K03653.
OMAi LDLYLWY.

Enzyme and pathway databases

BioCyci KCRY374847:GH12-1178-MONOMER.

Family and domain databases

HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OPF8.

Entry informationi

Entry nameiOGG1_KORCO
AccessioniPrimary (citable) accession number: B1L640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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