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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciKCRY374847:GH12-1178-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyaseUniRule annotation
Including the following 2 domains:
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Name:oggUniRule annotation
Ordered Locus Names:Kcr_1173
OrganismiKorarchaeum cryptofilum (strain OPF8)
Taxonomic identifieri374847 [NCBI]
Taxonomic lineageiArchaeaKorarchaeotaCandidatus Korarchaeum
ProteomesiUP000001686 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Probable N-glycosylase/DNA lyasePRO_1000100732Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi374847.Kcr_1173.

Structurei

3D structure databases

ProteinModelPortaliB1L640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
InParanoidiB1L640.
KOiK03653.
OMAiELCFCIL.

Family and domain databases

HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

B1L640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVDDLVNDV MRLKGSRVRE IIERRMREFE RERSDEELFK ELVFCLLTAN
60 70 80 90 100
FSAEGGLRIL ESLGDGIFTL SEEELAAKLA ELGHRYPRKR AEFIVEARKL
110 120 130 140 150
IPILRDIISS FRDERLLREW LVKNVKGLGY KEASHFLRNI GFKNVSIIDY
160 170 180 190 200
HILDLLMKYG ILEEKPKSLS RARYLMIESI LEEISRRTGI NLGELDLYLW

YIETGKVLK
Length:209
Mass (Da):24,480
Last modified:April 29, 2008 - v1
Checksum:iD81590C93751EFE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000968 Genomic DNA. Translation: ACB07919.1.
RefSeqiWP_012309816.1. NC_010482.1.
YP_001737602.1. NC_010482.1.

Genome annotation databases

EnsemblBacteriaiACB07919; ACB07919; Kcr_1173.
GeneIDi6094450.
KEGGikcr:Kcr_1173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000968 Genomic DNA. Translation: ACB07919.1.
RefSeqiWP_012309816.1. NC_010482.1.
YP_001737602.1. NC_010482.1.

3D structure databases

ProteinModelPortaliB1L640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi374847.Kcr_1173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB07919; ACB07919; Kcr_1173.
GeneIDi6094450.
KEGGikcr:Kcr_1173.

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
InParanoidiB1L640.
KOiK03653.
OMAiELCFCIL.

Enzyme and pathway databases

BioCyciKCRY374847:GH12-1178-MONOMER.

Family and domain databases

HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OPF8.

Entry informationi

Entry nameiOGG1_KORCO
AccessioniPrimary (citable) accession number: B1L640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: May 27, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.