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B1L5U5

- IMDH_KORCO

UniProt

B1L5U5 - IMDH_KORCO

Protein

Inosine-5'-monophosphate dehydrogenase

Gene

guaB

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.UniRule annotation

    Catalytic activityi

    Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

    Cofactori

    Potassium.UniRule annotation

    Enzyme regulationi

    Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei242 – 2421NADUniRule annotation
    Metal bindingi294 – 2941Potassium; via carbonyl oxygenUniRule annotation
    Metal bindingi296 – 2961Potassium; via carbonyl oxygenUniRule annotation
    Binding sitei297 – 2971IMPUniRule annotation
    Active sitei299 – 2991Thioimidate intermediateUniRule annotation
    Metal bindingi299 – 2991Potassium; via carbonyl oxygenUniRule annotation
    Binding sitei408 – 4081IMPUniRule annotation
    Metal bindingi462 – 4621Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi292 – 2943NADUniRule annotation

    GO - Molecular functioni

    1. adenyl nucleotide binding Source: InterPro
    2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. GMP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    GMP biosynthesis, Purine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Potassium

    Enzyme and pathway databases

    BioCyciKCRY374847:GH12-1082-MONOMER.
    UniPathwayiUPA00601; UER00295.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)
    Short name:
    IMP dehydrogenaseUniRule annotation
    Short name:
    IMPDUniRule annotation
    Short name:
    IMPDHUniRule annotation
    Gene namesi
    Name:guaBUniRule annotation
    Ordered Locus Names:Kcr_1078
    OrganismiKorarchaeum cryptofilum (strain OPF8)
    Taxonomic identifieri374847 [NCBI]
    Taxonomic lineageiArchaeaKorarchaeotaCandidatus Korarchaeum
    ProteomesiUP000001686: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Inosine-5'-monophosphate dehydrogenasePRO_0000415693Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi374847.Kcr_1078.

    Structurei

    3D structure databases

    ProteinModelPortaliB1L5U5.
    SMRiB1L5U5. Positions 9-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 15159CBS 1UniRule annotationAdd
    BLAST
    Domaini152 – 21160CBS 2UniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni334 – 3363IMP bindingUniRule annotation
    Regioni357 – 3582IMP bindingUniRule annotation
    Regioni381 – 3855IMP bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the IMPDH/GMPR family.UniRule annotation
    Contains 2 CBS domains.UniRule annotation

    Keywords - Domaini

    CBS domain, Repeat

    Phylogenomic databases

    eggNOGiCOG0516.
    HOGENOMiHOG000165755.
    KOiK00088.
    OMAiHGHSKNI.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01964. IMPDH.
    InterProiIPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view]
    PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
    PfamiPF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000130. IMPDH. 1 hit.
    SMARTiSM00116. CBS. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
    PROSITEiPS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1L5U5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIDRFEFAF TFNDVILLPG KTEIEPSNVD LTTRIGNIAL SIPILSSPMD    50
    TVTEEEMSIA MARMGGLGIL HRNCSVEEQV NMAKAVKRAE SFIIRDVITV 100
    SPEDSVEEAR RLMREHGISG LPVIVGRKLV GIVTRRDVYF AENGSLLVKD 150
    IMTKDPITVG PEITPQEARK IMARYKIEKL PVVSESGELI GLVTAKDVFY 200
    RESHPFATRD EEGRLRVGAA ISPFDIDRAK TLAPYVDVLV TDVAHFHNEN 250
    VISATKRIID EVGVPVIAGN IGTYEAAEEA ITRLDIIGLR VGIGSGSICT 300
    TGEVTGVAAP TLYAVASASE AVRKYSKDVA VIADGGIRGP GEAAKAFAMG 350
    ADAVMLGYAL AGTKEAPGST MMIGGKMYKI YRGMGSPSAR SKRFAMDRYS 400
    KPSKDIAEGI EGLVPYRGDV TTVVDRFVAG LKAAFGYVGA ANISEMKSKA 450
    RVALISHSGM SEIAPHDVKP LEKISD 476
    Length:476
    Mass (Da):51,195
    Last modified:April 29, 2008 - v1
    Checksum:i6AAC31F930E62260
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000968 Genomic DNA. Translation: ACB07824.1.
    RefSeqiYP_001737507.1. NC_010482.1.

    Genome annotation databases

    EnsemblBacteriaiACB07824; ACB07824; Kcr_1078.
    GeneIDi6094355.
    KEGGikcr:Kcr_1078.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000968 Genomic DNA. Translation: ACB07824.1 .
    RefSeqi YP_001737507.1. NC_010482.1.

    3D structure databases

    ProteinModelPortali B1L5U5.
    SMRi B1L5U5. Positions 9-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374847.Kcr_1078.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB07824 ; ACB07824 ; Kcr_1078 .
    GeneIDi 6094355.
    KEGGi kcr:Kcr_1078.

    Phylogenomic databases

    eggNOGi COG0516.
    HOGENOMi HOG000165755.
    KOi K00088.
    OMAi HGHSKNI.

    Enzyme and pathway databases

    UniPathwayi UPA00601 ; UER00295 .
    BioCyci KCRY374847:GH12-1082-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01964. IMPDH.
    InterProi IPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view ]
    PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
    Pfami PF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000130. IMPDH. 1 hit.
    SMARTi SM00116. CBS. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
    PROSITEi PS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OPF8.

    Entry informationi

    Entry nameiIMDH_KORCO
    AccessioniPrimary (citable) accession number: B1L5U5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3