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B1L5U5

- IMDH_KORCO

UniProt

B1L5U5 - IMDH_KORCO

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Protein
Inosine-5'-monophosphate dehydrogenase
Gene
guaB, Kcr_1078
Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421NAD By similarity
Metal bindingi294 – 2941Potassium; via carbonyl oxygen By similarity
Metal bindingi296 – 2961Potassium; via carbonyl oxygen By similarity
Binding sitei297 – 2971IMP By similarity
Active sitei299 – 2991Thioimidate intermediate By similarity
Metal bindingi299 – 2991Potassium; via carbonyl oxygen By similarity
Binding sitei408 – 4081IMP By similarity
Metal bindingi462 – 4621Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi292 – 2943NAD By similarity

GO - Molecular functioni

  1. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  2. adenyl nucleotide binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

BioCyciKCRY374847:GH12-1082-MONOMER.
UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
Ordered Locus Names:Kcr_1078
OrganismiKorarchaeum cryptofilum (strain OPF8)
Taxonomic identifieri374847 [NCBI]
Taxonomic lineageiArchaeaKorarchaeotaCandidatus Korarchaeum
ProteomesiUP000001686: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Inosine-5'-monophosphate dehydrogenaseUniRule annotation
PRO_0000415693Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi374847.Kcr_1078.

Structurei

3D structure databases

ProteinModelPortaliB1L5U5.
SMRiB1L5U5. Positions 9-92.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 15159CBS 1
Add
BLAST
Domaini152 – 21160CBS 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni334 – 3363IMP binding By similarity
Regioni357 – 3582IMP binding By similarity
Regioni381 – 3855IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG0516.
HOGENOMiHOG000165755.
KOiK00088.
OMAiHGHSKNI.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1L5U5-1 [UniParc]FASTAAdd to Basket

« Hide

MRIDRFEFAF TFNDVILLPG KTEIEPSNVD LTTRIGNIAL SIPILSSPMD    50
TVTEEEMSIA MARMGGLGIL HRNCSVEEQV NMAKAVKRAE SFIIRDVITV 100
SPEDSVEEAR RLMREHGISG LPVIVGRKLV GIVTRRDVYF AENGSLLVKD 150
IMTKDPITVG PEITPQEARK IMARYKIEKL PVVSESGELI GLVTAKDVFY 200
RESHPFATRD EEGRLRVGAA ISPFDIDRAK TLAPYVDVLV TDVAHFHNEN 250
VISATKRIID EVGVPVIAGN IGTYEAAEEA ITRLDIIGLR VGIGSGSICT 300
TGEVTGVAAP TLYAVASASE AVRKYSKDVA VIADGGIRGP GEAAKAFAMG 350
ADAVMLGYAL AGTKEAPGST MMIGGKMYKI YRGMGSPSAR SKRFAMDRYS 400
KPSKDIAEGI EGLVPYRGDV TTVVDRFVAG LKAAFGYVGA ANISEMKSKA 450
RVALISHSGM SEIAPHDVKP LEKISD 476
Length:476
Mass (Da):51,195
Last modified:April 29, 2008 - v1
Checksum:i6AAC31F930E62260
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000968 Genomic DNA. Translation: ACB07824.1.
RefSeqiYP_001737507.1. NC_010482.1.

Genome annotation databases

EnsemblBacteriaiACB07824; ACB07824; Kcr_1078.
GeneIDi6094355.
KEGGikcr:Kcr_1078.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000968 Genomic DNA. Translation: ACB07824.1 .
RefSeqi YP_001737507.1. NC_010482.1.

3D structure databases

ProteinModelPortali B1L5U5.
SMRi B1L5U5. Positions 9-92.
ModBasei Search...

Protein-protein interaction databases

STRINGi 374847.Kcr_1078.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB07824 ; ACB07824 ; Kcr_1078 .
GeneIDi 6094355.
KEGGi kcr:Kcr_1078.

Phylogenomic databases

eggNOGi COG0516.
HOGENOMi HOG000165755.
KOi K00088.
OMAi HGHSKNI.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .
BioCyci KCRY374847:GH12-1082-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OPF8.

Entry informationi

Entry nameiIMDH_KORCO
AccessioniPrimary (citable) accession number: B1L5U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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