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B1L5U2

- SYE_KORCO

UniProt

B1L5U2 - SYE_KORCO

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKCRY374847:GH12-1079-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Kcr_1075
OrganismiKorarchaeum cryptofilum (strain OPF8)
Taxonomic identifieri374847 [NCBI]
Taxonomic lineageiArchaeaKorarchaeotaCandidatus Korarchaeum
ProteomesiUP000001686: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Glutamate--tRNA ligasePRO_0000367802Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi374847.Kcr_1075.

Structurei

3D structure databases

ProteinModelPortaliB1L5U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi99 – 10911"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
InParanoidiB1L5U2.
KOiK01885.
OMAiAFRIIDT.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1L5U2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDVKELIVR LAAENALKYG KADTKAVIGK ILYMRPDLKQ NVRELIPLVE
60 70 80 90 100
EAVRAVNEMP KEALEGIVGE VKKEKKEEVR KWPDLPKAER GKVVTRVAPE
110 120 130 140 150
PNGYPTLGHA KGLLVPFIYA RLYDGKFLLR FEDTNPRVER LEYYEAIRNE
160 170 180 190 200
FSRLLEACEE ELGLSPGRWD EEIIESYHLE EMYSLAKKLI EAGKAYVCTC
210 220 230 240 250
PAAEVRKRRK LGISCDHRDQ PIEKNLELWE KMLNGGFREG EAHLRLKTDM
260 270 280 290 300
SHPNVTMRDP GIFRVIEAEH PIHGDKYRVY PVYDFSVSVM DSLTGVTHAF
310 320 330 340 350
RSKEFEPHVD VQRHIVRALG LREYEMIQFG RITVEGIPLS KRYIRPLVES
360 370 380 390 400
GILEGWDDPR IPTLRGLFRR GINPRAIVRF FYELGPSKVD ATVNMEAIAS
410 420 430 440 450
INRKILDPIA ERYMFVPNPI KAKIEGLTPP VIAQVEVHPD SKRKREIRLD
460 470 480 490 500
ESEVFIASSD LEGLKPGDEL RLRGLVNVTI RSVNPDEVSL RVSEEQRVKG
510 520 530 540 550
VKIIQWAPVR NGVPARLFVP ESPYSFRMLG GYGEPALRGI KEGEIVQFVR
560
VGFARLDRRD PLTFILSHD
Length:569
Mass (Da):65,142
Last modified:April 29, 2008 - v1
Checksum:iAD8CCE18820588F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000968 Genomic DNA. Translation: ACB07821.1.
RefSeqiYP_001737504.1. NC_010482.1.

Genome annotation databases

EnsemblBacteriaiACB07821; ACB07821; Kcr_1075.
GeneIDi6094352.
KEGGikcr:Kcr_1075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000968 Genomic DNA. Translation: ACB07821.1 .
RefSeqi YP_001737504.1. NC_010482.1.

3D structure databases

ProteinModelPortali B1L5U2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 374847.Kcr_1075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB07821 ; ACB07821 ; Kcr_1075 .
GeneIDi 6094352.
KEGGi kcr:Kcr_1075.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
InParanoidi B1L5U2.
KOi K01885.
OMAi AFRIIDT.

Enzyme and pathway databases

BioCyci KCRY374847:GH12-1079-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OPF8.

Entry informationi

Entry nameiSYE_KORCO
AccessioniPrimary (citable) accession number: B1L5U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3