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B1L5U2

- SYE_KORCO

UniProt

B1L5U2 - SYE_KORCO

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciKCRY374847:GH12-1079-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:Kcr_1075
    OrganismiKorarchaeum cryptofilum (strain OPF8)
    Taxonomic identifieri374847 [NCBI]
    Taxonomic lineageiArchaeaKorarchaeotaCandidatus Korarchaeum
    ProteomesiUP000001686: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 569569Glutamate--tRNA ligasePRO_0000367802Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi374847.Kcr_1075.

    Structurei

    3D structure databases

    ProteinModelPortaliB1L5U2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi99 – 10911"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiAFRIIDT.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1L5U2-1 [UniParc]FASTAAdd to Basket

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    MEDVKELIVR LAAENALKYG KADTKAVIGK ILYMRPDLKQ NVRELIPLVE    50
    EAVRAVNEMP KEALEGIVGE VKKEKKEEVR KWPDLPKAER GKVVTRVAPE 100
    PNGYPTLGHA KGLLVPFIYA RLYDGKFLLR FEDTNPRVER LEYYEAIRNE 150
    FSRLLEACEE ELGLSPGRWD EEIIESYHLE EMYSLAKKLI EAGKAYVCTC 200
    PAAEVRKRRK LGISCDHRDQ PIEKNLELWE KMLNGGFREG EAHLRLKTDM 250
    SHPNVTMRDP GIFRVIEAEH PIHGDKYRVY PVYDFSVSVM DSLTGVTHAF 300
    RSKEFEPHVD VQRHIVRALG LREYEMIQFG RITVEGIPLS KRYIRPLVES 350
    GILEGWDDPR IPTLRGLFRR GINPRAIVRF FYELGPSKVD ATVNMEAIAS 400
    INRKILDPIA ERYMFVPNPI KAKIEGLTPP VIAQVEVHPD SKRKREIRLD 450
    ESEVFIASSD LEGLKPGDEL RLRGLVNVTI RSVNPDEVSL RVSEEQRVKG 500
    VKIIQWAPVR NGVPARLFVP ESPYSFRMLG GYGEPALRGI KEGEIVQFVR 550
    VGFARLDRRD PLTFILSHD 569
    Length:569
    Mass (Da):65,142
    Last modified:April 29, 2008 - v1
    Checksum:iAD8CCE18820588F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000968 Genomic DNA. Translation: ACB07821.1.
    RefSeqiYP_001737504.1. NC_010482.1.

    Genome annotation databases

    EnsemblBacteriaiACB07821; ACB07821; Kcr_1075.
    GeneIDi6094352.
    KEGGikcr:Kcr_1075.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000968 Genomic DNA. Translation: ACB07821.1 .
    RefSeqi YP_001737504.1. NC_010482.1.

    3D structure databases

    ProteinModelPortali B1L5U2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374847.Kcr_1075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB07821 ; ACB07821 ; Kcr_1075 .
    GeneIDi 6094352.
    KEGGi kcr:Kcr_1075.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi AFRIIDT.

    Enzyme and pathway databases

    BioCyci KCRY374847:GH12-1079-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OPF8.

    Entry informationi

    Entry nameiSYE_KORCO
    AccessioniPrimary (citable) accession number: B1L5U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3