B1L5R5 (AROA_KORCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Kcr_1048

Organism

Korarchaeum cryptofilum (strain OPF8)

Taxonomic identifier

374847 [NCBI]

Taxonomic lineage

Archaea › Korarchaeota › Candidatus Korarchaeum

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 423	423	Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000204166

Sequences

	Sequence		Length	Mass (Da)
	B1L5R5 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 9C4EA6C63DB37761	FASTA	423	45,450
	10 20 30 40 50 60 MIEVKPSQAQ GSVRAPPSKS YSHRALAVSL LCEAPSKIEN ISRARDVIAT INAIKSFGAK 70 80 90 100 110 120 LSDNLTEIKI EPPQRPSIPD DVIDCGGSGT TIRFFAPIST LTEGGYTVLT GNDSLRRRPM 130 140 150 160 170 180 GPIIDAINKL GGWAISSRMN GLPPLIVRGG GLKGGEVEID GSISSQFFSG LMIASTRFER 190 200 210 220 230 240 GLKIKPIGEL VSRPYLEMTK EVLRRSGSHV ELNEEIKVEP VPPKGLEFKI PGDYGLAAFH 250 260 270 280 290 300 MLTASVTGGK VIVEDLDSTV PQADYAAIDV LRSFGVEVQE VGSRVIVEGR PKRGSKLNLK 310 320 330 340 350 360 DSPDIFPIAC VLASFVSEIS EIRGVAHARV KESDRVANMA SELKKVGVEV KELYDGLVIR 370 380 390 400 410 420 GGSPKGGVKL DSHGDHRIFM ALLALAAATR EGCIIEGEDS VADSYPSFLE DSMKLGIDVR YNL

References

[1]

"A korarchaeal genome reveals new insights into the evolution of the Archaea." Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L., Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A., Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G., Richardson P., Keller M., Stetter K.O. Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008) [PubMed: 18535141] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OPF8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000968 Genomic DNA. Translation: ACB07794.1.
RefSeq	YP_001737477.1. NC_010482.1.
3D structure databases
ProteinModelPortal	B1L5R5.
ModBase	Search...
Protein-protein interaction databases
STRING	B1L5R5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6094325.
GenomeReviews	Gene locus Kcr_1048 in contig CP000968_GR.
KEGG	kcr:Kcr_1048.
Phylogenomic databases
HOGENOM	HBG646626.
OMA	FADHRIA.
PhylomeDB	B1L5R5.
Enzyme and pathway databases
BioCyc	CKOR374847:KCR_1048-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_KORCO

Accession

Primary (citable) accession number: B1L5R5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program