B1L5J5 (B1L5J5_KORCO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NH(3)-dependent NAD(+) synthetase HAMAP MF_00193 RuleBase RU003812
EC=6.3.1.5 HAMAP MF_00193 RuleBase RU003812

Gene names

Name:	nadE HAMAP MF_00193
Ordered Locus Names:	Kcr_0978

Organism

Korarchaeum cryptofilum (strain OPF8)

Taxonomic identifier

374847 [NCBI]

Taxonomic lineage

Archaea › Korarchaeota › Candidatus Korarchaeum

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193 RuleBase RU003812
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193
Sequence similarities	Belongs to the NAD synthetase family. HAMAP MF_00193 RuleBase RU003811

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_00193 RuleBase RU003811 NAD HAMAP MF_00193 RuleBase RU003811 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00193 RuleBase RU003811
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP NAD+ synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro NAD+ synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	37 – 44	8	ATP By similarity HAMAP MF_00193
Sites
	Active site	39	1	By similarity HAMAP MF_00193

Sequences

	Sequence		Length	Mass (Da)
	B1L5J5 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 862A1E8883CA20DA	FASTA	262	29,578
	10 20 30 40 50 60 MLTLESLKLD MGKVKEIISG FIRGMVAGSR AEGIVLGISG GVDSAVLTKL CVDALGSERV 70 80 90 100 110 120 FGLILPDTRV TPEEDIKDAI DLAESLKIKY WRRDIDDIID SYERSEFYVH DHKLALGNLR 130 140 150 160 170 180 ARVRMSLLYY VANSRNLLVA GSGDRSEILI GYFTKYGDGG ADLLPIGDLY KTQVRWMAEW 190 200 210 220 230 240 LGLPERIARK PSSPRLWEGQ MAEKELGIPY ERIDLILHGL FDLRIDIDSL REEFGSDVDR 250 260 VMEMHSRSAH KRTMPPIARV RI

References

[1]

"A korarchaeal genome reveals new insights into the evolution of the Archaea." Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L., Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A., Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G., Richardson P., Keller M., Stetter K.O. Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008) [PubMed: 18535141] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OPF8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000968 Genomic DNA. Translation: ACB07724.1.
RefSeq	YP_001737407.1. NC_010482.1.
3D structure databases
ProteinModelPortal	B1L5J5.
ModBase	Search...
Protein-protein interaction databases
STRING	B1L5J5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6094255.
GenomeReviews	Gene locus Kcr_0978 in contig CP000968_GR.
KEGG	kcr:Kcr_0978.
Phylogenomic databases
HOGENOM	HBG351567.
OMA	DGAVDCH.
PhylomeDB	B1L5J5.
Family and domain databases
HAMAP	MF_00193. NadE. [Tree]
InterPro	IPR022310. NAD/GMP_synthase. IPR003694. NAD_synthase. IPR022926. NH(3)-dep_NAD(+)_synth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01916.
Pfam	PF02540. NAD_synthase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00552. NadE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B1L5J5_KORCO

Accession

Primary (citable) accession number: B1L5J5

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)